- ¥1380 - 2200
- LMAI Bio
- LM-9894R
- 进口/国产
- 2025年12月29日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test IF=1:50-200 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Cow, Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-9894R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
TFR2
- 抗体名：
转铁蛋白受体2抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Cow, Sheep,
- 免疫原：
KLH conjugated synthetic peptide derived from human TFR2/Transferrin Receptor 2:121-220/801
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test IF=1:50-200 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | TFR2 |
| 中文名称 | 转铁蛋白受体2抗体 |
| 别 名 | HFE 3; HFE3; HFE-3; MGC126368; TFR 2; TFR2; TFR-2; TFR2_HUMAN; TFRC 2; TFRC2; Transferrin receptor protein 2; Transferrin Receptor 2. |
 |
Specific References (1) | bs-9894R has been referenced in 1 publications. [IF=3.70] Zhang, Ying, et al. "Calcium channel blockers ameliorate iron overload-associated hepatic fibrosis by altering iron transport and stellate cell apoptosis." Toxicology and Applied Pharmacology (2016). WB ; Mouse. PubMed:27095094 |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 细胞生物 信号转导 通道蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Sheep, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 89kDa |
| 细胞定位 | 细胞浆 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TFR2/Transferrin Receptor 2:121-220/801 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Function: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Subunit: Homodimer. Subcellular Location: Cell membrane and Cytoplasm. Lacks the transmembrane domain. Probably intracellular. Tissue Specificity: Predominantly expressed in liver. While the alpha form is also expressed in spleen, lung, muscle, prostate and peripheral blood mononuclear cells, the beta form is expressed in all tissues tested, albeit weakly. DISEASE: Defects in TFR2 are a cause of hemochromatosis type 3 (HFE3) [MIM:604250]. HFE3 is a disorder of iron hemostasis resulting in iron overload and has a phenotype indistinguishable from that of hereditary hemochromatosis (HH). HH is characterized by abnormal intestinal iron absorption and progressive increase of total body iron, which results in midlife in clinical complications including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy, and susceptibility to liver cancer. Since the disease complications can be effectively prevented by regular phlebotomies, early diagnosis is most important to provide a normal life expectancy to the affected subjects. Similarity: Belongs to the peptidase M28 family. M28B subfamily. SWISS: Q9UP52 Gene ID: 7036 Database links: Entrez Gene: 7036 Human Entrez Gene: 50765 Mouse Entrez Gene: 288562 Rat Omim: 604720 Human SwissProt: Q9UP52 Human SwissProt: Q9JKX3 Mouse SwissProt: B2GUY2 Rat Unigene: 544932 Human Unigene: 21757 Mouse Unigene: 59926 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Involvement in disease;Defects in TFR2 are a cause of hemochromatosis type 3 (HFE3) . HFE3 is a disorder of iron hemostasis resulting in iron overload and has a phenotype indistinguishable from that of hereditary hemochromatosis (HH). HH is characterized by abnormal intestinal iron absorption and progressive increase of total body iron, which results in midlife in clinical complications including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy, and susceptibility to liver cancer. Since the disease complications can be effectively prevented by regular phlebotomies, early diagnosis is most important to provide a normal life expectancy to the affected subjects. |
| 产品图片 |  Blank control (blue line): HL60(fixed with 70% ethanol Overnight at 4℃. Cells stained with Primary Antibody for 30 min at room temperature). Primary Antibody (green line): Rabbit Anti-TFR2 antibody (bs-9894R),Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody (white blue line): Goat anti-rabbit IgG-PE,Dilution: 1μg /test. |
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文献和实验配体与受体分子结合的实验外，研究人员还进行了实验，以确定这种结合是否参与了网状细胞的入侵过程。获得了表达TfR1较低表面水平的jkRBCs的突变克隆，并与间日疟原虫和恶性疟原虫merozoites孵育。在突变体细胞中，间日疟原虫的侵袭减少了10倍，这说明了转铁蛋白受体TfR1在侵袭过程中的重要性。相比之下，恶性疟原虫的入侵不受可用TfR1减少的影响。最后，将针对PvRBP2b n端3个表位的单克隆抗体加入到巴西和泰国的间日疟原虫分离株中，可以抑制红细胞的侵袭。因此，如果TfR1不可用或PvRBP2
1mg ,所以食物中铁为10～15mg就能满足需要。铁的吸收与体内贮存铁多少有关。吸收进入肠粘膜的铁根据机体需要或直接进入骨髓供造血使用，或与肠粘膜去铁蛋白结合以铁蛋白（ferritin）形式贮存其中。 体内铁的转运需要转铁蛋白（transferrin）。它是分子量为76000的β 1 糖蛋白，有2个铁结合位。胞浆膜上有转铁蛋白受体，铁-转铁蛋白复合物与受体结合，通过受体调节的胞饮作用进入细胞，铁分离后，去铁的转铁蛋白被释出细胞外继续发挥
的吸收与体内贮存铁多少有关。吸收进入肠粘膜的铁根据机体需要或直接进入骨髓供造血使用，或与肠粘膜去铁蛋白结合以铁蛋白（ferritin）形式贮存其中。 体内铁的转运需要转铁蛋白（transferrin）。它是分子量为76000的β 1 糖蛋白，有2个铁结合位。胞浆膜上有转铁蛋白受体，铁-转铁蛋白复合物与受体结合，通过受体调节的胞饮作用进入细胞，铁分离后，去铁的转铁蛋白被释出细胞外继续发挥作用。 铁的排泄主要通过肠粘膜细胞脱落以及胆汁、尿液
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