- ¥1380 - 2200
- LMAI Bio
- LM-6674R
- 进口/国产
- 2025年12月30日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-6674R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
KCNK3
- 抗体名：
酸敏感钾离子通道蛋白3抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep,
- 免疫原：
KLH conjugated synthetic peptide derived from human KCNK3:51-150/394 <Extracellular>
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | KCNK3 |
| 中文名称 | 酸敏感钾离子通道蛋白3抗体 |
| 别 名 | cTBAK 1; Acid sensitive potassium channel protein TASK 1; Cardiac two pore background K(+) channel; K2p3.1; OAT1; potassium channel, subfamily K, member 3; rTASK; TASK 1; TBAK1; TWIK related acid sensitive K+ channel; Two pore potassium channel KT3.1; KCNK3; TASK; TASK1; PPH4; TASK; TASK-1; TBAK1; KCNK3_HUMAN. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 神经生物学 通道蛋白 细胞膜受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 43kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KCNK3:51-150/394 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]. Function: pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. Subcellular Location: Membrane; Multi-pass membrane protein (Potential). Tissue Specificity: Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon. Similarity: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. SWISS: O14649 Gene ID: 3777 Database links: Entrez Gene: 3777 Human Entrez Gene: 16527 Mouse Entrez Gene: 29553 Rat Omim: 603220 Human SwissProt: O14649 Human SwissProt: Q53SU2 Human SwissProt: O35111 Mouse SwissProt: O54912 Rat Unigene: 645288 Human Unigene: 439936 Mouse Unigene: 15536 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Sample: Pancreas (Mouse) Lysate at 40 ug Primary: Anti-KCNK3 (bs-6674R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 43 kD Observed band size: 43 kD  Sample: Placenta (Mouse) Lysate at 40 ug Primary: Anti-KCNK3 (bs-6674R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 43 kD Observed band size: 43 kD  Blank control(blue): H9C2 (fixed with 2% paraformaldehyde (10 min)) . Primary Antibody:Rabbit Anti- KCNK3 antibody(bs-6674R), Dilution: 6ug in 100 uL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-FITC(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA. |
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文献和实验Sci Adv：蒋若天 / 温祥毅揭示钾离子通道参与健康和衰老视网膜视觉信号调控新机制
间隙的 pH 值从 7.5 降至 6.9 1,2，并参与负反馈（negative feedback）信号的传导以及周围接收野（surround receptive field）的形成 3-6，然而这种生理性的瞬时酸化是否对向前传到 RGC 的信号有正反馈（feedforward）效应？在 RGC 上，AMPA 受体、NMDA 受体、酸敏感离子通道（acid-sensing ion channel，ASIC）等多种离子通道都具有酸敏感性 7-9。然而，这些酸敏感通道只对病理性酸化（如 pH 双孔钾离子
或抑制的通道optoXR，给光激活后其改变的是胞内激酶系统，影响细胞活动。因此，光遗传学技术的核心技术差异在于光敏感通道的选择。 光遗传学的基本原理（Karl Deisseroth, et al., Annu. Rev. Biomed. Eng., 2014）常见的光敏感通道几种激活神经元的通道蛋白： ChR2(H134R)：470nm蓝光激发。ChR2的突变体，该蛋白质可以产生两倍的光电流，但通道开关速度也比野生的ChR2慢了一倍。 ChETA：470nm左右蓝光激发。ChR2的突变
与鉴定的植物基因的例子很多，其中有Fe（Ⅱ）转运蛋白基因IRTⅠ、Fe（Ⅲ）螯合物还原酶基因FRO2，拟南芥菜的NH4-transporter，西红柿中两个铁调控的离子转运蛋白cDNAs（LeIRT1,LeIRT2），玉米YS1（yellow stripel）基因以及大麦SFD1等。另外在研究钾离子通道蛋白方面结合定点诱变、随机诱变等对通道蛋白的结构及功能可作出很好的遗传分析。 三、实验原理 缺铁胁迫时，酵母主要通过高亲和系统来转运铁离子，有如下几个步骤：①转录
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