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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
上海联迈生物工程有限公司
- 库存:
大量
- 目录编号:
LM-8632R
- 克隆性:
多克隆
- 抗原来源:
Rabbit
- 保质期:
1年
- 抗体英文名:
CBR1
- 抗体名:
羰基还原酶1抗体
- 宿主:
Rabbit
- 适应物种:
Human, Mouse, Rat,
- 免疫原:
KLH conjugated synthetic peptide derived from human CBR1:201-277/277
- 亚型:
IgG
- 形态:
Lyophilized or Liquid
- 应用范围:
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
- 浓度:
1mg/ml
- 保存条件:
Store at -20 °C
- 规格:
100ul 200ul
| 英文名称 | CBR1 |
| 中文名称 | 羰基还原酶1抗体 |
| 别 名 | 15 hydroxyprostaglandin dehydrogenase [NADP+]; 15-hydroxyprostaglandin dehydrogenase [NADP+]; Carbonyl reductase [NADPH] 1; Carbonyl Reductase 1; CBR 1; CBR1; CBR1_HUMAN; CRN; NADPH dependent carbonyl reductase 1; NADPH-dependent carbonyl reductase 1; Prostaglandin 9 ketoreductase; Prostaglandin 9-ketoreductase; Prostaglandin E(2) 9 reductase; Prostaglandin-E(2) 9-reductase; SDR21C1. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 细胞生物 免疫学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 30kDa |
| 细胞定位 | 细胞浆 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CBR1:201-277/277 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013] Function: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. Subcellular Location: Cytoplasm. Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. SWISS: P16152 Gene ID: 873 Database links: Entrez Gene: 873 Human Omim: 114830 Human SwissProt: P16152 Human Unigene: 606200 Human Unigene: 88778 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 | ![]() Sample: Small intestine (Mouse) Lysate at 40 ug Primary: Anti-CBR1 (bs-8632R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 30 kD Observed band size: 30 kD |
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文献和实验HBeAb(+)的HBV感染者中,加查前S1抗原是非常必要的。 三、为什么检测HBV-DNA还要检测前S1抗原? 1.前S1蛋白是乙型肝炎病毒(HBV)外膜蛋白的主要专长部分,它含有肝细胞受体,在HBV感染细胞和机体免疫应答方面起重要作用。在病毒感染机体的整个周期中,前S1蛋白的独特功能,使其能够较充分的反应机体的体液免疫状况,直至病程的转归过程(如早期诊断,急性肝炎前S1抗原阴转是病毒清除的最早迹象,反之疾病将发展至慢性肝炎等临床诊断以及前S1抗原阴转,前S1抗体出现等免疫
突变基因携带者的杂交图式,由于它的一条染色体的DNA分子中酶A的识别点发生改变,酶切后的DNA片段较原来的长,所以出现一长一短两个片段。③是突变基因纯合子,也就是患者,酶A和B的酶切片段虽然是各有一个,但A的片段比正常的个体长,所以杂交带出现的位置也有改变。从图23-8可以看出研究RFLP的两个重要因素,一是要制备合适的探针,二是要用尽可能多的各种限制性内切酶进行酶切和杂交。 1974年首次用RFLP作为遗传学分析的方法。1978年简悦威和Dozy等第一次用人体β珠蛋白基因作为探针
,包括α1抗胰蛋白酶、抗凝血酶、C1抑制剂和纤维蛋白溶解抑制剂等等。它们选择性作用于不同丝氨酸蛋白酶,其功能丧失将导致种种疾病。如:α1抗胰蛋白酶缺陷肺气肿或肝硬变;抗凝血酶缺陷血栓病;C1抑制剂缺陷血管水肿;神经抑丝酶包含体家族性脑病(FENIB)等。 分子内两个结构特征对抑丝酶抑制蛋白酶具有重要作用,一是显露的16氨基酸肽环,能被蛋白酶分解;二是由5 条肽链构成的β片层结构。抑丝酶发挥催化功能经过显著的构象变化。亚稳态活性状态的抑丝酶在同系蛋白酶的作用下形成酰基-酶,显露的肽环作为第6股肽
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