Ubiquitin泛素蛋白抗体

Ubiquitin泛素蛋白抗体

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  • ¥1380 - 2200
  • LMAI Bio
  • LM-7944R
  • 进口/国产
  • 2025年11月28日
  • WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
  • Rabbit
  • Human, Mouse, Chicken, Cow, Sheep,
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    • 详细信息
    • 技术资料
    • 供应商

      上海联迈生物工程有限公司

    • 库存

      大量

    • 目录编号

      LM-7944R

    • 克隆性

      多克隆

    • 抗原来源

      Rabbit

    • 保质期

      1年

    • 抗体英文名

      Ubiquitin

    • 抗体名

      泛素蛋白抗体

    • 宿主

      Rabbit

    • 适应物种

      Human, Mouse, Chicken, Cow, Sheep,

    • 免疫原

      KLH conjugated synthetic peptide derived from human Ubiquitin C-terminuse:63-74/76

    • 亚型

      IgG

    • 形态

      Lyophilized or Liquid

    • 应用范围

      WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)

    • 浓度

      1mg/ml

    • 保存条件

      Store at -20 °C

    • 规格

      100ul  200ul

    Ubiquitin泛素蛋白抗体
    英文名称 Ubiquitin
    中文名称 泛素蛋白抗体
    别    名 FLJ25987; MGC8385; RPS27A; RPS 27A; UBA52; UBA 52; UBA80; UBA 80; UBB; UBC; UB; UBCEP1; UBCEP2; UBCEP 1; UBCEP 2; UBCEP-1; UBCEP-2; Ubiquitin; ubiquitin B; UBC_HUMAN; UBB_HUMAN; RS27A_HUMAN; HMG20; Ubiquitin carboxyl extension protein 80; Ubiquitin; Polyubiquitin-C; Polyubiquitin-B.  
    规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价
    说 明 书 100ul  200ul
    研究领域 肿瘤  细胞生物  免疫学  神经生物学  细胞凋亡  泛素  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Chicken, Cow, Sheep, 
    产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 8.5kDa
    细胞定位 细胞核 细胞浆 
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human Ubiquitin C-terminuse:63-74/76 
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    PubMed PubMed
    产品介绍 background:
    This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

    Function:
    Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

    Subcellular Location:
    Cytoplasm. Nucleus.

    Similarity:
    Belongs to the ubiquitin family. 
    Contains 9 ubiquitin-like domains.

    SWISS:
    P0CG48

    Gene ID:
    7314

    Database links:

    Entrez Gene: 281370 Cow

    Entrez Gene: 100049794 Horse

    Entrez Gene: 7314 Human

    Entrez Gene: 22187 Mouse

    Entrez Gene: 192255 Rat

    Omim: 191339 Human

    SwissProt: P0CG53 Cow

    SwissProt: Q8MKD1 Horse

    SwissProt: P0CG47 Human

    SwissProt: P0CG48 Human

    SwissProt: P62988 Human

    SwissProt: P0CG49 Mouse

    SwissProt: P62991 Mouse

    SwissProt: P0CG51 Rat

    SwissProt: P62989 Rat

    Unigene: 356190 Human

    Unigene: 520348 Human

    Unigene: 282093 Mouse

    Unigene: 371592 Mouse

    Unigene: 110618 Rat

    Unigene: 1253 Rat

    Unigene: 3761 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

    泛素及类泛素蛋白(Ubls) 存在在多种细胞中,有多种细胞调控的功能,如细胞增殖、凋亡、细胞周期及DNA修复等。但泛素途径的异常会导致人类疾病的产生,包括多种形式的肿瘤的发生,神经退变等都与泛素有关。

    相关产品:
    Ubiquitin 1-76 peptides (bs-10803P);
    产品图片 Ubiquitin泛素蛋白抗体
    Sample: 
    HepG2(Human) Cell Lysate at 30 ug
    Primary: Anti-Ubiquitin (bs-7944R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 8.5 kD
    Observed band size: 12 kD

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