- ¥780 - 2200
- LMAI Bio
- LM-7723R
- 进口/国产
- 2025年12月10日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1ug/Test IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Guinea Pig,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-7723R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
REC8
- 抗体名：
减数分裂重组蛋白家族REC8抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Guinea Pig,
- 免疫原：
KLH conjugated synthetic peptide derived from human REC8:22-120/547
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1ug/Test IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
50ul 100ul 200ul
| 英文名称 | REC8 |
| 中文名称 | 减数分裂重组蛋白家族REC8抗体 |
| 别 名 | Cohesin Rec8p; Meiotic recombination protein REC8 homolog; Meiotic recombination protein REC8-like 1; rec8; REC8 homolog (yeast); REC8_HUMAN; REC8L; Rec8L1; Rec8p. |
| 规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul 200ul |
| 研究领域 | 细胞生物 细胞周期蛋白 细胞分化 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Guinea Pig, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1ug/Test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 60kDa |
| 细胞定位 | 细胞核 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human REC8:22-120/547 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II. Function: Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity). Subunit: Interacts (phosphorylated and unphosphorylated form) with SMC3. Interacts with SYCP3. Interacts (phosphorylated and unphosphorylated form) with SMC1B. Does not interact with SMC1A. Interacts with RAD51. Subcellular Location: Nucleus. Chromosome. Tissue Specificity: Expressed in testis and thymus. Similarity: Belongs to the rad21 family. SWISS: O95072 Gene ID: 9985 Database links: Entrez Gene: 9985 Human Entrez Gene: 56739 Mouse Entrez Gene: 290227 Rat Omim: 608193 Human SwissProt: O95072 Human SwissProt: Q8C5S7 Mouse SwissProt: Q6AYJ4 Rat Unigene: 419259 Human Unigene: 23149 Mouse Unigene: 108612 Rat
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Sample: HT29 Cell (Human) Lysate at 40 ug Primary: Anti-REC8 (bs-7723R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 60 kD Observed band size: 65 kD  Sample: Thymus (Mouse) Lysate at 40 ug Primary: Anti-REC8 (bs-7723R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 60 kD Observed band size: 60 kD  Blank control (Black line):Molt4 (Black). Primary Antibody (green line): Rabbit Anti-REC8 antibody (bs-7723R) Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody (white blue line): Goat anti-rabbit IgG-AF647 Dilution: 1μg /test. Protocol The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at room temperature. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed. |
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文献和实验，从而将目的基因靶向性地导入肿瘤细胞。Khare等将抗人癌胚抗原(CEA)单链抗体编码基因与env基因重组，使反转录病毒将“自杀基因”――一氧化氮合成酶(NOS)靶向导人CEA阳性的肿瘤细胞，并通过过度合成NOS杀死肿瘤细胞。 靶向转移目的基因策略的工作原理 另一个例子是腺病毒。腺病毒载体在感染靶细胞时，首先依靠通过病毒衣壳(capsid)上的纤维蛋白(nber)头部的knob结构域识别并结合靶细胞表面的“柯萨奇病毒和腺病毒受体”(CAR)，然后通过衣壳的五邻体
复旦大学生物医学研究院王磊教授一直致力于利用分子遗传学手段寻找人类生殖疾病相关致病基因，并利用细胞、动物模型对相关基因功能展开深入的研究，在本次研究中，他利用遗传及功能基因组学手段揭开了人类卵子成熟障碍之谜。 文章摘要 人类生殖繁衍主要依赖于成熟卵细胞和精子融合形成的受精卵，但是阻滞人卵细胞成熟的遗传机制至今未知。 研究人员利用外显子组测序技术对不孕症患者四代家系中的五名成员进行研究，其中三名患者因卵母细胞第一次减数分裂受到抑制
消失。间日疟原虫优先侵入表达高水平这种受体的网状细胞。网织红细胞结合蛋白家族PvRBP2b已被证明优先与表达TfR1的网织红细胞结合。一组多国研究人员证实了TfR1/PvRBP2b受体/配体在网状细胞入侵中的性质和重要性，他们的发现最近发表在《科学》杂志上。调查最初，他们发现，如果使用酶将TfR1受体从网状细胞表面去除，或者使用抗TfR1单克隆抗体阻断受体位点，重组PvRBP2b与网状细胞的结合就会消失。免疫沉淀实验表明，PvRBP2b与TfR1的结合具有直接特异性;间日疟原虫网状结合蛋白家族
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