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- Biogems
- AF-450-10-100µg
- 美国
- 2025年07月13日
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靶点/蛋白质：MSPDKQMAV LPRRERNRQ AAAANPENS RGKGRRGQR GKNRGCVLT AIHLNVTDL GLGYETKEE LIFRYCSGS CDAAETTYD KILKNLSRN RRLVSDKVG QACCRPIAF DDDLSFLDD NLVYHILRK HSAKRCGCI
来源：E. Coli
特异性：Frog, Monkey, Mouse, Rat
官网链接：http://www.bio-gems.com/recombinant-proteins/neurotrophins/animal-free-recombinant-human-gdnf.html
商品关键词：Animal-Free Recombinant Human GDNF,AF-450-10-100µg ,Biogems
简单描述：GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson's disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional human GDNF ligand is a disulfide-linked homodimer, of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, one of which (Cys 101) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration. Manufactured using all non-animal reagents.
Source: E. Coli
Purity:Above 98% as determined by SDS-PAGE Analysis.
Biological Activity: The ED50 was determined by the proliferation of rat C6 cells is < 0.1 ng/ml, corresponding to a specific activity of > 1 x 107 units/mg.
Cell Type: Neurons
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