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Sigma-Aldrich货号L3024脂多糖(别名:LPS
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- 文献和实验
- 技术资料
- 英文名：
Lipopolysaccharides(LPS)
- CAS号：
93572-42-0
- 保质期：
1年
- 保存条件：
2-8°C
- 库存：
10⁺瓶
- 供应商：
上海睿安生物19121878899
- 规格：
10mg/瓶
Sigma-Aldrich货号L3024-5mg脂多糖(别名:LPS)来源于大肠杆菌0111:B4上海睿安生物19121878899默克Merck-Roche-Millipore-Sigma官方正式授权代理商
Sigma-Aldrich货号L3024-10mg脂多糖(别名:LPS)来源于大肠杆菌0111:B4上海睿安生物19121878899默克Merck-Roche-Millipore-Sigma官方正式授权代理商
Sigma-Aldrich货号L3024-25mg脂多糖(别名:LPS)来源于大肠杆菌0111:B4上海睿安生物19121878899默克Merck-Roche-Millipore-Sigma官方正式授权代理商
脂多糖来源于大肠杆菌0111:B4
purified by ion-exchange chromatography,TLR ligand tested
别名:LPS
属性
biological source:Escherichia coli(O111:B4)
form:lyophilized powder
purified by:ion-exchange chromatography
impurities:<1% Protein,<1% RNA
color:white to yellow cast
solubility water:soluble
shipped in:ambient
storage temp:2-8°C
Quality Level:200
说明
Biochem/physiol Actions
脂多糖（LPS）位于膜的外层，并且在非包封的菌株中暴露在细胞表面上。它们有助于外膜的完整性，并保护细胞免受胆汁盐和亲脂性抗生素的作用。
General description
该产品是从大肠杆菌血清型O111：B4中提取的，并已通过离子交换进行纯化。来源菌株来自私人保藏。该LPS血清型已用于刺激B细胞并诱导人肝细胞中的NOS。
Application
脂多糖（LPS）是革兰氏阴性菌细胞壁的特征组分。LPS及其脂质A部分可通过能够识别常见的病原体相关分子模式（PAMP）的Toll样受体蛋白家族成员Toll样受体4（TLR4）刺激先天性免疫系统细胞。
Other Notes
为了全面了解我们针对客户研究提供的各种脂多糖产品，建议您访问我们的碳水化合物分类页面。
Preparation Note
该产品可溶于水（5mg/mL）或细胞培养基（1mg/mL），并产生浑浊的淡黄色溶液。在涡旋震荡并升温至70-80℃后，可在盐水溶液中获得更加浓缩但仍然浑浊的溶液（20mg/mL）。脂多糖可在各种溶剂中形成胶束。在水和磷酸盐缓冲盐水中可观察到浑浊的溶液。通过有机溶剂无法获得更澄清的溶液。在甲醇会产生含有漂浮物的混浊悬浮液，而在水中则产生均匀的浑浊溶液。
同行评审论文(部分:文献)
The Effect of Lipopolysaccharide-Induced Experimental Bovine Mastitis on Clinical Parameters, Inflammatory Markers, and the Metabolome: A Kinetic Approach.
Carl-Fredrik Johnzon et al.
Frontiers in immunology, 9, 1487-1487 (2018-07-11)
Mastitis is an inflammatory condition of the mammary tissue and represents a major problem for the dairy industry worldwide. The present study was undertaken to study how experimentally induced acute bovine mastitis affects inflammatory parameters and changes in the metabolome.
Lysosomal Protein Lamtor1 Controls Innate Immune Responses via Nuclear Translocation of Transcription Factor EB.
Yoshitomo Hayama et al.
Journal of immunology (Baltimore, Md. : 1950), 200(11), 3790-3800 (2018-04-25)
Amino acid metabolism plays important roles in innate immune cells, including macrophages. Recently, we reported that a lysosomal adaptor protein, Lamtor1, which serves as the scaffold for amino acid-activated mechanistic target of rapamycin complex 1 (mTORC1), is critical for the
Effects of differential supplementation of fatty acids during the peripartum and breeding periods of Holstein cows: II. Neutrophil fatty acids and function, and acute phase proteins.
F T Silvestre et al.
Journal of dairy science, 94(5), 2285-2301 (2011-04-29)
The objectives were to evaluate the effects of differential supplementation of Ca salts (CS) of fatty acids (FA) on plasma acute phase proteins and both FA composition and function (i.e., activity and cytokine production) of neutrophils, during the peripartum and
Neutrophil recruitment in endotoxin-induced murine mastitis is strictly dependent on mammary alveolar macrophages.
Sharon Elazar et al.
Veterinary research, 41(1), 10-10 (2009-10-16)
Mastitis, inflammation of the mammary tissue, is a common disease in dairy animals and mammary pathogenic Escherichia coli (MPEC) is a leading cause of the disease. Lipopolysaccharide (LPS) is an important virulence factor of MPEC and inoculation of the mammary
Inhibition of hypoxia-inducible factors limits tumor progression in a mouse model of colorectal cancer.
Jessica E S Shay et al.
Carcinogenesis, 35(5), 1067-1077 (2014-01-11)
Hypoxia-inducible factors (HIFs) accumulate in both neoplastic and inflammatory cells within the tumor microenvironment and impact the progression of a variety of diseases, including colorectal cancer. Pharmacological HIF inhibition represents a novel therapeutic strategy for cancer treatment. We show here
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文献和实验该产品被引用文献
Sigma-Aldrich货号L3024-5mg脂多糖(别名:LPS)来源于大肠杆菌0111:B4上海睿安生物19121878899默克Merck-Roche-Millipore-Sigma官方正式授权代理商
Sigma-Aldrich货号L3024-10mg脂多糖(别名:LPS)来源于大肠杆菌0111:B4上海睿安生物19121878899默克Merck-Roche-Millipore-Sigma官方正式授权代理商
Sigma-Aldrich货号L3024-25mg脂多糖(别名:LPS)来源于大肠杆菌0111:B4上海睿安生物19121878899默克Merck-Roche-Millipore-Sigma官方正式授权代理商
脂多糖来源于大肠杆菌0111:B4
purified by ion-exchange chromatography,TLR ligand tested
别名:LPS
属性
biological source:Escherichia coli(O111:B4)
form:lyophilized powder
purified by:ion-exchange chromatography
impurities:<1% Protein,<1% RNA
color:white to yellow cast
solubility water:soluble
shipped in:ambient
storage temp:2-8°C
Quality Level:200
说明
Biochem/physiol Actions
脂多糖（LPS）位于膜的外层，并且在非包封的菌株中暴露在细胞表面上。它们有助于外膜的完整性，并保护细胞免受胆汁盐和亲脂性抗生素的作用。
General description
该产品是从大肠杆菌血清型O111：B4中提取的，并已通过离子交换进行纯化。来源菌株来自私人保藏。该LPS血清型已用于刺激B细胞并诱导人肝细胞中的NOS。
Application
脂多糖（LPS）是革兰氏阴性菌细胞壁的特征组分。LPS及其脂质A部分可通过能够识别常见的病原体相关分子模式（PAMP）的Toll样受体蛋白家族成员Toll样受体4（TLR4）刺激先天性免疫系统细胞。
Other Notes
为了全面了解我们针对客户研究提供的各种脂多糖产品，建议您访问我们的碳水化合物分类页面。
Preparation Note
该产品可溶于水（5mg/mL）或细胞培养基（1mg/mL），并产生浑浊的淡黄色溶液。在涡旋震荡并升温至70-80℃后，可在盐水溶液中获得更加浓缩但仍然浑浊的溶液（20mg/mL）。脂多糖可在各种溶剂中形成胶束。在水和磷酸盐缓冲盐水中可观察到浑浊的溶液。通过有机溶剂无法获得更澄清的溶液。在甲醇会产生含有漂浮物的混浊悬浮液，而在水中则产生均匀的浑浊溶液。
同行评审论文(部分:文献)
The Effect of Lipopolysaccharide-Induced Experimental Bovine Mastitis on Clinical Parameters, Inflammatory Markers, and the Metabolome: A Kinetic Approach.
Carl-Fredrik Johnzon et al.
Frontiers in immunology, 9, 1487-1487 (2018-07-11)
Mastitis is an inflammatory condition of the mammary tissue and represents a major problem for the dairy industry worldwide. The present study was undertaken to study how experimentally induced acute bovine mastitis affects inflammatory parameters and changes in the metabolome.
Lysosomal Protein Lamtor1 Controls Innate Immune Responses via Nuclear Translocation of Transcription Factor EB.
Yoshitomo Hayama et al.
Journal of immunology (Baltimore, Md. : 1950), 200(11), 3790-3800 (2018-04-25)
Amino acid metabolism plays important roles in innate immune cells, including macrophages. Recently, we reported that a lysosomal adaptor protein, Lamtor1, which serves as the scaffold for amino acid-activated mechanistic target of rapamycin complex 1 (mTORC1), is critical for the
Effects of differential supplementation of fatty acids during the peripartum and breeding periods of Holstein cows: II. Neutrophil fatty acids and function, and acute phase proteins.
F T Silvestre et al.
Journal of dairy science, 94(5), 2285-2301 (2011-04-29)
The objectives were to evaluate the effects of differential supplementation of Ca salts (CS) of fatty acids (FA) on plasma acute phase proteins and both FA composition and function (i.e., activity and cytokine production) of neutrophils, during the peripartum and
Neutrophil recruitment in endotoxin-induced murine mastitis is strictly dependent on mammary alveolar macrophages.
Sharon Elazar et al.
Veterinary research, 41(1), 10-10 (2009-10-16)
Mastitis, inflammation of the mammary tissue, is a common disease in dairy animals and mammary pathogenic Escherichia coli (MPEC) is a leading cause of the disease. Lipopolysaccharide (LPS) is an important virulence factor of MPEC and inoculation of the mammary
Inhibition of hypoxia-inducible factors limits tumor progression in a mouse model of colorectal cancer.
Jessica E S Shay et al.
Carcinogenesis, 35(5), 1067-1077 (2014-01-11)
Hypoxia-inducible factors (HIFs) accumulate in both neoplastic and inflammatory cells within the tumor microenvironment and impact the progression of a variety of diseases, including colorectal cancer. Pharmacological HIF inhibition represents a novel therapeutic strategy for cancer treatment. We show here
相关实验
Elabscience|肺泡巨噬细胞研究必看：LPS诱导急性肺炎模型制备与检测全攻略
率高达30%–45%[1]。尽管机械通气等支持手段不断进步，但针对其核心病理环节的特异性治疗手段仍然匮乏[2]。 巨噬细胞是肺部固有免疫的核心细胞，在炎症调控、组织修复与纤维化进程中扮演关键角色[3]。肺泡巨噬细胞（Alveolar Macrophages, AMs）约占肺泡免疫细胞的70%，定居于肺泡腔表面，被称为免疫细胞中的"清道夫"，能够直接吞噬吸入肺部的病原体和有害颗粒物[4]。在稳态下，AMs主要表现为M2抗炎表型，维持组织免疫耐受；当遭遇脂多糖（LPS）等病原相关分子模式刺激后，AMs
；Sigma Aldrich ) 。 ( 7 ) N-糖酰胺酶 F：来源于脑膜脓毒性黄杆菌的 N-糖酰胺酶 F。（Roche Applied Science) ( 保存于 -25~-15℃）。 ( 8 ) 10 mmol/L HCl 溶液，pH 2.2。 ( 9 ) C18 色谱柱：BondElntC 18 色谱柱（Varian，Palo Alto , CA ) (室温保存）。 ( 10 ) 乙腈，纯度 99.5% 以上（Sigma Aldrich ) 。 ( 11
Elabscience | BV2细胞M1极化造模与流式检测，这份Protocol请收好
转染、RNA干扰和CRISPR编辑等遗传操作，为信号通路机制研究提供了便利。 2. 对LPS等刺激反应灵敏，可诱导明确的M1/M2极化：BV2细胞表面高表达TLR4受体，LPS刺激后通过MyD88依赖途径激活NF-κB和MAPK信号通路，诱导经典M1型极化，释放大量促炎因子如TNF-α、IL-1β、IL-6、iNOS和COX-2等[5,7]。同时，通过加入IL-4、IL-13等因子可诱导M2型极化，表达ARG-1、CD206、IL-10等抗炎标志物。 3. 实验结果可重复性好：相较于原代小胶质细胞，BV
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文献支持
Sigma-Aldrich货号L3024脂多糖(别名:LPS)来源于大肠杆菌0111:B4上海睿安生物19121878899默克Merck-Roche-Millipore-Sigma官方正式授权代理商
￥6058.86
