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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
上海联迈生物工程有限公司
- 库存:
大量
- 目录编号:
LM-6583R
- 克隆性:
多克隆
- 抗原来源:
Rabbit
- 保质期:
1年
- 抗体英文名:
RNASE4
- 抗体名:
血管生成素核糖核酸酶4抗体(肌萎缩性侧索硬化症蛋白)
- 宿主:
Rabbit
- 适应物种:
Human, Mouse, Rat, Pig, Horse,
- 免疫原:
KLH conjugated synthetic peptide derived from human RNASE4:51-147/147
- 亚型:
IgG
- 形态:
Lyophilized or Liquid
- 应用范围:
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)
- 浓度:
1mg/ml
- 保存条件:
Store at -20 °C
- 规格:
100ul 200ul
| 英文名称 | RNASE4 |
| 中文名称 | 血管生成素核糖核酸酶4抗体(肌萎缩性侧索硬化症蛋白) |
| 别 名 | RAB1; Ribonuclease 4; Ribonuclease A B1; Ribonuclease, RNase A family, 4; RNAS4_HUMAN; RNase 4; RNS4. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 肿瘤 心血管 细胞生物 信号转导 血管内皮细胞 细胞骨架 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Horse, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 14kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RNASE4:51-147/147 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in four transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2013]. Function: This RNase has marked specificity towards the 3' side of uridine nucleotides. Subcellular Location: Secreted. Similarity: Belongs to the pancreatic ribonuclease family. SWISS: P34096 Gene ID: 6038 Database links: Entrez Gene: 465205 Chimpanzee Entrez Gene: 616089 Cow Entrez Gene: 6038 Human Entrez Gene: 58809 Mouse Entrez Gene: 100174757 Orangutan Entrez Gene: 396976 Pig Entrez Gene: 56759 Rat Omim: 601030 Human SwissProt: Q8HZQ0 Chimpanzee SwissProt: P15467 Cow SwissProt: P34096 Human SwissProt: Q9JJH1 Mouse SwissProt: Q5NVS4 Orangutan SwissProt: P15468 Pig SwissProt: O55004 Rat Unigene: 730830 Human Unigene: 202665 Mouse Unigene: 1742 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 | ![]() Tissue/cell: rat lung tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-RNASE4/Angiogenin Polyclonal Antibody, Unconjugated(bs-6583R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining |
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文献和实验佚名 肌萎缩性侧索硬化症(amyotrophic lateral sclerosis,ALS)的病变累及锥体束上、下神经元,上神经元在大脑皮质,其轴索经过内囊、脑干及皮质脊髓束与脑运动神经核或脊髓前角下运动神经元相联系。本病发病年龄在40~50岁,男多于女,临床起病缓慢,表现为进行性上、下肢肌萎缩,无力,锥体束损害及脑干运动神经核受损,一般无感觉障碍,病程
肌萎缩性侧索硬化症(amyotrophic lateral sclerosis,ALS)的病变累及锥体束上、下神经元,上神经元在大脑皮质,其轴索经过内囊、脑干及皮质脊髓束与脑运动神经核或脊髓前角下运动神经元相联系。本病发病年龄在40~50岁,男多于女,临床起病缓慢,表现为进行性上、下肢肌萎缩,无力,锥体束损害及脑干运动神经核受损,一般无感觉障碍,病程一般2~6年。 本病的病变多自脊髓向上发展,波及脑干乃至大脑的运动
Extraction Kit 产品说明:本试剂盒用于从哺乳动物组织和培养细胞中提取核蛋白和胞质蛋白,提取制备过程简便。制备的核蛋白和胞浆蛋白能保持天然活性,并且纯度较高。提取的蛋白可用于进一步的转录因子活性分析、凝胶阻滞实验(gel shift assay)、免疫共沉淀、Western Blotting、酶活性测定等后续蛋白质研究,可以每次从1×107个培养细胞或200mg 组织中提取所需要的蛋白质,可以使用50次。储存条件:2-~8℃。 产品特点: 1.最大限度保持蛋白质活性
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