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CD95/FAS载脂蛋白1抗体

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  • ¥780 - 2200
  • LMAI Bio
  • LM-6477R
  • 进口/国产
  • 2026年05月11日
  • WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
  • Rabbit
  • Human, Mouse, Rat, Pig,
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    • 详细信息
    • 询价记录
    • 文献和实验
    • 技术资料
    • 供应商：

      上海联迈生物工程有限公司

    • 库存：

      大量

    • 目录编号：

      LM-6477R

    • 克隆性：

      多克隆

    • 抗原来源：

      Rabbit

    • 保质期：

      1年

    • 抗体英文名：

      CD95/FAS

    • 抗体名：

      载脂蛋白1抗体

    • 宿主：

      Rabbit

    • 适应物种：

      Human, Mouse, Rat, Pig,

    • 免疫原：

      KLH conjugated synthetic peptide derived from human FAS/Apo-1/CD95:81-170/335 <Extracellular>

    • 亚型：

      IgG

    • 形态：

      Lyophilized or Liquid

    • 应用范围：

      WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）

    • 浓度：

      1mg/ml

    • 保存条件：

      Store at -20 °C

    • 规格：

      50ul  100ul  200ul

    CD95/FAS载脂蛋白1抗体
    英文名称 CD95/FAS
    中文名称 载脂蛋白1抗体
    别    名 Apo-1; ALPS 1A; ALPS1A; APO 1; Apo 1 antigen; APO 1 cell surface antigen; Apo-1 antigen; APO1; Apo1 antigen; APO1 cell surface antigen; Apoptosis antigen 1; Apoptosis mediating surface antigen FAS; Apoptosis-mediating surface antigen FAS; APT 1; APT1; CD 95; CD 95 antigen; CD95; CD95 antigen; Delta Fas; Delta Fas/APO 1/CD95; Delta Fas/APO1/CD95; FAS 1; FAS 827dupA; Fas AMA; FAS; FAS Antigen; FAS1; FASLG receptor; FASTM; TNF receptor superfamily, member 6; TNFRSF 6; TNFRSF6; TNR6_HUMAN; Tumor necrosis factor receptor superfamily member 6.  
    产品细节图片1 Specific References  (1)     |     bs-6477R has been referenced in 1 publications.
    [IF=3.53] Fang C, Zhang J, Qi D, Fan X, Luo J, et al. (2014) Evodiamine Induces G2/M Arrest and Apoptosis via Mitochondrial and Endoplasmic Reticulum Pathways in H446 and H1688 Human Small-Cell Lung Cancer Cells. PLoS ONE 9(12): e115204.   WB ;  Human.  
    PubMed:25506932
    规格价格 50ul/780元 购买    100ul/1380元 购买    200ul/2200元 购买    大包装/询价
    说 明 书 50ul  100ul  200ul
    研究领域 细胞生物  免疫学  细胞凋亡  细胞类型标志物  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, Pig, 
    产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 34kDa
    细胞定位 细胞膜 分泌型蛋白 
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human FAS/Apo-1/CD95:81-170/335 <Extracellular>
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    PubMed PubMed
    产品介绍 background:
    Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

    Function:
    Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

    Subunit:
    Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD.

    Subcellular Location:
    Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2, 3, 4, 5, 6: Secreted.

    Tissue Specificity:
    Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.

    Post-translational modifications:
    N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.

    DISEASE:
    Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.

    Similarity:
    Contains 1 death domain.
    Contains 3 TNFR-Cys repeats.

    SWISS:
    P25445

    Gene ID:
    355

    Database links:

    Entrez Gene: 355 Human

    Entrez Gene: 14102 Mouse

    Entrez Gene: 246097 Rat

    Omim: 134637 Human

    SwissProt: P25445 Human

    SwissProt: P25446 Mouse

    SwissProt: Q63199 Rat

    Unigene: 244139 Human

    Unigene: 1626 Mouse

    Unigene: 162521 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
     
    产品图片 产品细节图片2
    Sample: 
    serum (Rat) Lysate at 40 ug
    plasma (Rat) Lysate at 40 ug
    Primary: Anti-CD95 (bs-6477R) at 1/1000 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 34 kD
    Observed band size: 42 kD

    产品细节图片3
    Blank control(blue):Mouse Kidney (fixed with 2% paraformaldehyde for 10 min at 37℃). 
    Primary Antibody:Rabbit Anti-CD95/FAS antibody (bs-6477R,Green); Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; 
    Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions; 
    Secondary Antibody: Goat anti-rabbit IgG-FITC(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.

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