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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
4°C, sealed storage, away from moisture
- 英文名:
RO6885247 tetrahydrochloride
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- 规格:
5 mg/10 mg/50 mg
| 规格: | 5 mg | 产品价格: | ¥1000.0 |
|---|---|---|---|
| 规格: | 10 mg | 产品价格: | ¥1600.0 |
| 规格: | 50 mg | 产品价格: | ¥4800.0 |
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RG7800 tetrahydrochloride
MCE 国际站:RG7800 tetrahydrochloride
产品活性:RG7800 hydrochloride 是一种可口服的 SMN2 剪接调节剂,对 SMN2 剪接及 SMN 蛋白的 EC1.5x 值分别为 23 nM 和 87 nM。
研究领域:Cell Cycle/DNA Damage
作用靶点:DNA/RNA Synthesis
In Vitro: RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; and is the first small molecule SMN2 splicing modifier to enter human clinical trials.
In Vivo: RG7800 is a favorable agent metabolism and pharmacokinetic (DMPK) profile in the rat and in cynomolgus monkey with good oral bioavailability. RG7800 (1, 3, 10 mg/kg, p.o.) dose-dependently elevates the SMN protein level in the brain and in peripheral tissue of Δ7 mice.
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文献和实验Use of Biotin-Labeled Probes on Plant Chromosomes
reaction is produced by the addition of hydrogen peroxide and the dye, 3,3′-diaminobenzidine tetrahydrochloride dihyhdrate (DAB). The signal is seen as a dark precipitate (Fig. 1 ) that maintains color intensity for several years, provided slides are kept
因子 DWT1 在 FM 中高度富集表达,基于该生信分析结果,研究团队使用遗传学方法进一步分析了 DWT1 对花序的影响(图 2e,f),即 DWT1 参与花序的发育,调控水稻 FM 的活性,这也是 DWT1 与花发育功能相关的首次报道。 (图 2a) (图 2b) (图 2d,e,f) 利用 monocle 算法的拟时序分析,我们重建了花细胞亚群的两条发育轨迹:生殖器官(FM、pa、lo、st 等花组织)轨迹和非生殖器官轨迹(cb、le、sl, rg 等苞叶类附生组织
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Proteomics: Methods and Protocols 2009-6 蛋白质组学方法和技术 by J?rg Reinders and Albert Sickmann Product Description Since the development of the concept of “proteomics”, great progress has granted deeper insight into the cellular network
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