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Vasonatrin Peptide (VNP)
CAS No. : 141676-35-9
MCE 国际站：Vasonatrin Peptide (VNP)
产品活性：Vasonatrin peptide (VNP) 是心房钠尿肽 (ANP) 和C型利尿钠肽 (CNP) 的嵌合体，具有高效的静脉扩张和利钠活性。
研究领域：Others
作用靶点：Others
In Vitro: Vasonatrin peptide binds with both natriuretic peptide receptor A and B, but with a preference for B. VNP-stimulated cGMP is 11-fold greater in NPRB than NPRA.
In Vivo: The high-fat diet-fed streptozotocin-induced diabetic Sprague-Dawley rats are subjected to ischemia-reperfusion operation. VNP treatment (100 g/kg iv, 10 min before reperfusion) significantly improved the instantaneous first derivation of left ventricle pressure (LV dP/dtmax) and LV systolic pressure and reduced LV end-diastolic pressure, apoptosis index, caspase-3 activity, plasma creatine kinase (CK), and lactate dehydrogenase (LDH) activities. Treatment hypoxia-induced pulmonary hypertension (HPH) with Vasonatrin peptide for 1 week significantly reduceS mean pulmonary arterial pressure, pulmonary vascular resistance, RVH and muscularization of the pulmonary arteries. Acute intravenous administration of 50 microg/kg Vasonatrin peptide significantly ameliorates pulmonary haemodynamics in HPH rats.
相关产品：PEG300 | SBE-β-CD | Corn oil | Tween 80 | Polyethylene glycol 12-hydroxystearate | JC-1 | DTT | CFSE | Digitonin | Lipopolysaccharides | Thiazolyl Blue | D-Luciferin potassium salt | (2-Hydroxypropyl)-β-cyclodextrin | Methyl-β-cyclodextrin | Biotin | Monocrotaline | Auxinole | Nile Red | 3X FLAG peptide TFA | FLAG peptide | Tocofersolan | DAPI dihydrochloride | Propidium Iodide | Cremophor EL | Yoda 1 | IPTG | Calcein-AM | GsMTx4 TFA
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文献和实验Establishing MHC Class I Peptide Motifs
Major histocompatibility complex (MHC) class I peptide motifs are used on a regular basis to identify and predict MHC class I ligands and CD8+ T-cell epitopes. This approach is above all an invaluable tool for the identification of disease
35Analysis of Single Nucleotide Polymorphisms in the Interleukin-1B Gene Using 5 Nuclease Assays
Interleukins are soluble peptide molecules that mediate the interaction between immunocompetent and haematopoietic cells and between the immune and neuroendocrine systems (1 ). They are produced by a variety of activated cells and exert
Epitope Analysis Using Synthetic Peptide Repertoires Prepared by SPOT Synthesis Technology
Antibodies recognize and bind their target protein antigens via surface accessible interaction sites, the epitopes (Fig. 35.1), which can involve amino acid side chain and backbone contacts along a linear segment of the antigen amino acid
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