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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1161233-85-7
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1210.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥500.0 |
| 规格： | 5 mg | 产品价格： | ￥1100.0 |
| 规格： | 10 mg | 产品价格： | ￥1850.0 |
| 规格： | 50 mg | 产品价格： | ￥6800.0 |
| 规格： | 100 mg | 产品价格： | ￥9980.0 |
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BTZ043
CAS No. : 1161233-85-7
MCE 国际站：BTZ043
产品活性：BTZ043 是 DprE1 的抑制剂，它对结核分枝杆菌 H37Rv (M. tuberculosis H37Rv) 和耻垢分枝杆菌 (Mycobacterium smegmatis) 的 MIC 值分别为 2.3 nM 和 9.2 nM。
研究领域：Anti-infection
作用靶点：Bacterial | Antibiotic
In Vitro: The MIC of BTZ043 against M. tuberculosis H37Rv and Mycobacterium smegmatis are 1 ng/mL (2.3 nM) and 4 ng/mL (9.2 nM), respectively. The in vitro activity of BTZ043 against 30 Nocardia brasiliensis isolates is also tested. The MIC50 and MIC90 values for BTZ043 are 0.125 and 0.25 μg/mL. The MIC for N. carnea ATCC 6847 is 0.003μg/mL, for N. transvalensis ATCC 6865 is 0.003μg/mL, for N. brasiliensis NCTC10300 is 0.03 μg/mL, and for N. brasiliensis HUJEG-1 is 0.125μg/mL. The MIC value for M. tuberculosis H37Rv is 0.000976 μg/mL. The MIC value of BTZ-043 is >64 μg/mL for Escherichia coli ATCC 25922 and S. aureus ATCC 29213.
In Vivo: Four weeks of treatment with BTZ043 reduces the bacterial burden in the lungs and spleens by 1 and 2 logs, respectively, at the concentrations used. Additional results suggest that BTZ043 efficacy is time-rather than dose-dependent. Acute (5 g/kg) and chronic (25 and 250 mg/kg) toxicology studies in uninfected mice show that, even at the highest dose tested, there are no adverse anatomical, behavioral, or physiological effects after one month.
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文献和实验Substrate Tablete(antibody developed in goat) St. Louis,Mo 63178, USAAffinity isolated antibody adsorbed Lot # 043H6178With bovine horse and human serum protein Cat # 0h176Lot # 055H4835Lot # A-2179Tween 80Laboratories ,Detroit,Michigan ,USA1 drop of Tween
HLA 系统中的连锁不平衡 连锁不平衡(1inkagedisequilibrium)是指在某一群体中，不同座位上某两个等位基因出现在同一条单体型上的频率与预期值之间有明显的差异。连锁不平衡的程度可以由连锁不平衡参数厶来表示。HLA系统中经典的工类区域座位和Ⅱ类区域座位均存在连锁不平衡。 如在白人中，HLA-A1基因频率为0．275，HLA-B8基因频率为0.157。A1与B8在同一条单体型上的预期频率为0．043(0．275X0．157)，但在群体中A1
.0 %GRA % 81.043±6.814 323 22.0-96
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