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- 2025年07月13日
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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
915191-42-3
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥3387.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥650.0 |
| 规格： | 5 mg | 产品价格： | ￥2550.0 |
| 规格： | 10 mg | 产品价格： | ￥4550.0 |
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MF498
CAS No. : 915191-42-3
MCE 国际站：MF498
产品活性：MF498 是一种具有选择性和口服活性的 E 前列腺素受体 4 (EP4) 拮抗剂，Ki 值为 0.7 nM。MF498可用于炎症研究，如类风湿和骨关节炎。
研究领域：GPCR/G Protein
作用靶点：Prostaglandin Receptor
In Vitro: MF498 (0.01 nM-10 μM, 30 min) inhibits PGE2-stimulated cAMP accumulation with IC50 values of 1.7 and 17 nM in the absence and presence of 10% serum, respectively.
MF498 (0.01 and 0.1 μM, 30 min) inhibits FBS and PDGF-BB-induced VSMC proliferation in rat VSMCs.
MF498 (0.1 μM, 30 min) reduced PDGF-induced cyclin D1 and PCNA expression in rat VSMCs.
MF498 (0.1 μM, 30 min) inhibits the PDGF-BB-induced migration.
In Vivo: MF498 (0-20 mg/kg, p.o.) inhibits paw swelling in rats with adjuvant-induced arthritis (AIA).
MF498 (0-30 mg/kg, p.o.) attenuates the EP4 agonist-(L-902688)-induced hyperalgesia in guinea pigs.
MF498 (20 mg/kg, p.o.) shows 100% bioavailability, resulting in plasma concentration of 1.2 μM at 6 h.
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文献和实验Identification of Mycoplasmas by Dot Immunobinding on Membrane Filtration (MF Dot)
The definitive identification of mycoplasmas is usually based on serological procedures, including growth inhibition (1 ,2 ), metabolic inhibition (3 ,4 ), immunofluorescence (5 –7 ), and immunobinding assays (8 –14 ). The technique
The Adjuvant MF59: A 10-Year Perspective Gary Ott, Ramachandran Radhakrishnan,
antigens which, in general, are poorly immunogenic when administered in the absence of an adjuvant (1 ). The purpose of this chapter is to summarize our extensive experience with the oil-in-water emulsion adjuvant MF59 and to emphasize to the reader
. Prefractionation and simplification of biological samples prior to downstream MS analysis is showing some virtue in obtaining greater depth of protein analysis. The MicroFlow MF10 is a prefractionation device for low volume, low abundance complex samples
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