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- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
Almitrine bismesylate; Almitrine bismethanesulfonate; Almitrine dimesylate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
29608-49-9
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥165.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥100.0 |
| 规格： | 10 mg | 产品价格： | ￥150.0 |
| 规格： | 50 mg | 产品价格： | ￥450.0 |
| 规格： | 100 mg | 产品价格： | ￥750.0 |
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Almitrine mesylate
CAS No. : 29608-49-9
MCE 国际站：Almitrine mesylate
产品活性：Almitrine mesylate 是一种外周化学感受器的激动剂，选择性抑制 Ca2+依赖性的 K+ 通道。
研究领域：Membrane Transporter/Ion Channel
作用靶点：Potassium Channel
In Vitro: Almitrine inhibits the activity of a high-conductance (152±13 pS), Ca2+-dependent K+ channel by decreasing its open probability. The IC50 value of the effect is 0.22 μM. The inhibitory effect of Almitrine on Ca2+-dependent K+ channels also is observed in GH3 cells. Almitrine at concentrations up to 10 μM does not affect whole-cell voltage-dependent K+, Ca2+, or Na+ currents in rat or rabbit cells. However, this concentration of Almitrine significantly inhibits the Ca2+-dependent component of K+ currents in rat chemoreceptor cells.
In Vivo: Almitrine acts via the peripheral arterial chemoreceptors raising carotid sinus nerve output and minute ventilation. Almitrine also has a pulmonary vascular action causing a dose-dependent constriction and dilatation. At low doses Almitrine enhances hypoxic pulmonary vasoconstriction and may improve the overall ventilation/perfusion ratio.
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Cenicriviroc Mesylate（甲磺酸西尼替洛韦，研发代号TAK-652）是一款高活性、双靶点的CCR2/CCR5特异性拮抗剂，兼具优异的抗病毒与抗炎活性，是炎症性疾病及艾滋病病毒感染相关科研领域的核心工具化合物。该产品由知名生命科学试剂品牌MedChemExpress (MCE) 提供，货号HY-14882A，凭借精准的靶点抑制能力、明确的药理机制及丰富的科研验证数据，被广泛应用于纤维化疾病、HIV病毒感染机制及抗炎药理的深度研究，目前已有7篇相关科研文献引用该产品开展试验
Detection of BCR-ABL Mutations and Resistance to Imatinib Mesylate
The major mechanism of imatinib resistance for patients with chronic myeloid leukemia (CML) is clonal expansion of leukemic cells with mutations in the Bcr-Abl fusion tyrosine kinase that reduce the capacity of imatinib to inhibit kinase
-4 and C-5 centers ( 3 ). After formatron of the mesylate, from the recycled material the amine function is introduced through azrde displacement of the mesylate, followed by reduction ( 4 ) and protectron with the t -BOC group. Finally, the lactone
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