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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1000669-72-6
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥250.0 |
| 规格： | 5 mg | 产品价格： | ￥500.0 |
| 规格： | 10 mg | 产品价格： | ￥800.0 |
| 规格： | 25 mg | 产品价格： | ￥1680.0 |
| 规格： | 50 mg | 产品价格： | ￥2604.0 |
| 规格： | 100 mg | 产品价格： | ￥3906.0 |
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KW-2449
CAS No. : 1000669-72-6
MCE 国际站：KW-2449
产品活性：KW-2449是多靶点激酶抑制剂，对FLT3，ABL，ABLT315I和 Aurora kinase 的 IC50 值分别为6.6，14，4 和 48 nM。
研究领域：Protein Tyrosine Kinase/RTK | Epigenetics | Cell Cycle/DNA Damage | Apoptosis
作用靶点：FLT3 | FGFR | Bcr-Abl | Aurora Kinase | Apoptosis
In Vitro: KW-2449 shows growth inhibitory activities against FLT3/ITD-, FLT3/D835Y-, and wt-FLT3/FL-expressing 32D cells, MOLM-13 and MV4;11 with GI50 values of 0.024, 0.046, 0.014, 0.024, and 0.011 μM, respectively. KW-2449 suppresses the phosphorylations of FLT3 (P-FLT3) and its downstream molecule phospho-STAT5 (P-STAT5) in MOLM-13 cells in a dose-dependent manner. KW-2449 increases the percentage of cells in the G1 phase of the cell cycle and reciprocally reduced the percentage of cells in the S phase, resulting in the increase of apoptotic cell population.
In Vivo: Oral administration of KW-2449 shows dose-dependent and significant tumor growth inhibition in FLT3-mutated xenograft model with minimum bone marrow suppression. In FLT3 wild-type human leukemia, it induces the reduction of phosphorylated histone H3, G2/M arrest, and apoptosis. In imatinib-resistant leukemia, KW-2449 contributes to release of the resistance by the simultaneous down-regulation of BCR/ABL and Aurora kinases. Furthermore, the antiproliferative activity of KW-2449 is confirmed in primary samples from AML and imatinib-resistant patients. The inhibitory activity of KW-2449 is not affected by the presence of human plasma protein, such as α1-acid glycoprotein.
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文献和实验Ampicillin resistance (beta-lactamase) promoter -35 region: 2170-2175; -10 region: 2193-2198 Transcription start point: 2205 SV40 origin of replication: 2449-2584 SV40 early promoter Enhancer (72-bp tandem repeats): 2282-2353
型内循环罐型用于烃类发酵生产酵母取得成功以后，近一、二十年来开发的结构多种多样。国内已有100吨罐用于山梨醇发酵试验，400吨罐用于衣康酸的生产和200吨以上多种规模的谷氨酸生产，有环隙气升式、外循环气升式等不同构型，都有比较显著的效果。有关这类罐型的功耗指标，一般的内循环气升式罐功耗为3.5kw/m3，其KLa仅为350/h；循环气升式反应器的功耗为5kw/m3，其KLa亦仅400/h。国外对这类反应器的主要开发进展是追求节约功耗、提高溶氧水平，如多层筛板式反应器的功耗水平为3.5kw/m3
处理风量 (m3/min) 压缩机 KW 电源 V/50HZ
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