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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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MedChemExpress LLC
- CAS号：
1386455-76-0
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥3828.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1630.0 |
| 规格： | 5 mg | 产品价格： | ￥3600.0 |
| 规格： | 10 mg | 产品价格： | ￥6000.0 |
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Complement factor D-IN-1
CAS No. : 1386455-76-0
MCE 国际站：Complement factor D-IN-1
产品活性：Complement factor D-IN-1是一种有效的和选择性的小分子可逆因子(small-molecule reversible factor d) 抑制剂，在FD硫酯分解荧光实验和MAC沉积测定中IC50值分别为0.006 和 0.05 μM。
作用靶点：Complement System
In Vitro: The highly specific S1 serine protease factor D (FD) plays a central role in the amplification of the complement alternative pathway (AP) of the innate immune system. Complement factor D-IN-1 (compound 2) shows similar potency against human and monkey FD (IC50s in FD thioesterolytic assays of 0.005 μM and in 50% serum MAC deposition assays of 0.011 μM for both human and monkey).
In Vivo: Complement factor D-IN-1 displays an excellent oral PK profile in Sprague–Dawley rats and, following an oral dose (10 mg/kg) in Brown Norway rats, demonstrates a good distribution and sustained exposure in ocular tissues including the neural retina and the posterior eye cup (PEC), which comprises the sclera, retinal pigmented epithelium, and choroid. Mean exposure levels in plasma, the PEC, and the retina at 6 h after dosing are 0.36, 0.43, and 0.09 μM, respectively.
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文献和实验Cell cycle analysis of Escherichia coli cells
Example (continues): C period calculated from the oriC/terC ratio: 49 min D period = (C+D) � C D period = 76 min � 49 min = 27 min The theoretical exponential DNA histogram:
Cancers：浙江大学/协和深圳医院基于 LC-MS/MS 的挥发性有机化合物生物标志物分析用于肺癌的早期检测
-7）、2-戊酮（TG-8）、丙烯醛（TG -11)、壬醛 (TG-19)、癸醛 (TG-20) 和巴豆醛 (TG-22)，在肺癌患者和对照组之间存在显著差异，其中浸润性肺腺癌 (IAC) 的差异最为显著 ，其敏感性和特异性最高为 70% 和 76%。 图 1. 不同饮食后呼气中 VOC 浓度的变化。A-C。食用一些常见食物后人体呼气中羰基 VOCs 浓度的变化；D. 饮用不同糖液后呼出气中 TG-4 浓度的变化；E-F。值和误差条表示平均值±SE。 该研究调查了呼出气中羰基挥发性有机化合物 (VOC
【资源】《Separation Methods in Proteomics》
Proteomics: Fluorescent Detection of Proteins, Glycoproteins, and Phospoproteins in Two-Dimensional (2D) Gels Chapter 25 Direct Immunoprobing on Glyoxyl Agarose Composite Gels Chapter 26 Nuclear Magnetic Resonance-Driven Chemical Proteomics
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