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- 文献和实验
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Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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MedChemExpress LLC
- CAS号：
877877-35-5
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10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1010.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥320.0 |
| 规格： | 5 mg | 产品价格： | ￥800.0 |
| 规格： | 10 mg | 产品价格： | ￥1150.0 |
| 规格： | 50 mg | 产品价格： | ￥4000.0 |
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TW-37
CAS No. : 877877-35-5
MCE 国际站：TW-37
产品活性：TW-37 是一种有效的 Bcl-2 抑制剂，作用于 Mcl-1，Bcl-2 和 Bcl-xL，Ki 值分别为 260，290 和 1110 nM。
研究领域：Apoptosis
作用靶点：Bcl-2 Family
In Vitro: TW-37 (TW37) is a novel nonpeptide small-molecule inhibitor designed using a structure-based design strategy. TW-37 targets the BH3-binding groove in Bcl-2 where proapoptotic Bcl-2 proteins, such as Bak, Bax, and Bid bind. In fluorescence polarization-based binding assays using recombinant Bcl-2 and Bcl-xL proteins, TW-37 binds to Bcl-2 and Bcl-xL with Ki values of 290 and 1110 nM, respectively. TW-37 has an IC50 of 1.8 μM for endothelial cells but shows no cytotoxic effects for fibroblasts at concentrations up to 50 μM. The mechanism of TW-37-induced endothelial cell death is apoptosis, in a process mediated by mitochondrial depolarization and activation of caspase-9 and caspase-3. The effect of TW-37 on endothelial cell apoptosis is not prevented by coexposure to the growth factor milieu secreted by tumor cells. Inhibition of the angiogenic potential of endothelial cells (i.e., migration and capillary sprouting assays) and expression of the angiogenic chemokines CXCL1 and CXCL8 are accomplished at subapoptotic TW-37 concentrations (0.005-0.05 μM). TW-37 is a potent Bcl-2 and Mcl-1 inhibitor. In fluorescence polarization-based binding assays using recombinant Bcl-2, Bcl-xL, and Mcl-1 proteins, TW-37 binds to Bcl-2, Bcl-xL, and Mcl-1 with Ki values of 290, 1,110 and 260 nM, respectively.
In Vivo: A murine model of humanized vasculature is used to investigate the biological effect of TW-37 (TW37) on human microvascular endothelial cell in vivo. Using this model, a significant decrease is observed in total blood vessel number (P<0.05) comparing both 3 and 30 mg/kg TW-37 against vehicle control. In addition to reduction in total number of blood vessels, an unusual number of occluded vessels are occurring in the treated groups. The levels of vessel occlusion are assessed by counting completely blocked vessels and determining their number as a percentage of total vessel number. TW-37 concentration mediates a significant increase in the number of occluded vessels when compared with control.
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文献和实验前段时间，小编的一位朋友为了升职称，辛辛苦苦写了第一篇英文，准备投篇SCI，说是印度的某个杂志，有去年的影响因子，接受率很高。小编听到后，赶快检索了下，却发现该杂志近期已被 SCI 数据库剔除，还好及时制止了那位朋友。1为此，小编特地查询并整理了过去的 12 个月里，已被 SCI 数据库动态剔除或停止检索的杂志，共37本！包括：生物医学类 19 本，工程技术类 8 本，化学类 2 本，物理类 1 本，数学类 4 本，综合类 1 本等。 2那么，杂志被剔除 SCI 的原因，通常有哪些呢？① 自引
CD37 分子 CD37 常用单克隆抗体或代号： HD28,HH1 主要表达细胞： B,(T,M,G) [B] 分子质量(kDa)和结构： gp40- 52(TM4- SF) 功 能：参与信号转导 CD37 Possibly involved in signal transduction, belongs to tetraspanin family Positive
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