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- 2025年07月12日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
280744-09-4
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥715.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥295.0 |
| 规格： | 5 mg | 产品价格： | ￥650.0 |
| 规格： | 10 mg | 产品价格： | ￥1100.0 |
| 规格： | 50 mg | 产品价格： | ￥4800.0 |
| 规格： | 100 mg | 产品价格： | ￥7886.0 |
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SB 216763
CAS No. : 280744-09-4
MCE 国际站：SB 216763
产品活性：SB 216763是有效，选择性和ATP竞争性的 GSK-3 抑制剂，抑制GSK-3α和GSK-3β的 IC50 为34.3 nM。
研究领域：PI3K/Akt/mTOR | Stem Cell/Wnt | Autophagy
In Vitro: SB-216763 (10-20 μM) induces β-catenin mediated-transcription in a dose-dependent manner in HEK293 cells. SB-216763 (10, 15 and 20 μM) can maintain mESCs with a pluripotent-like morphology in long-term culture. SB-216763 (10 μM) can maintain J1 mESCs in a pluripotent state for more than a month.
SB-216763 inhibits GSK-3 with IC50 of 34 nM.
SB-216763 is equally effective at inhibiting human GSK-3α and GSK-3β.
In Vivo: SB216763 (20 mg/kg, i.v.) significantly improves the survival of BLM-treated mice. Mice randomized to receive BLM plus SB216763 shows a noteworthy reduction, compared with BLM-treated mice. SB216763 (20 mg/kg, i.v.) reduces the magnitude of BLM-induced alveolitis. SB 216763 (0.2 mg/kg, i.v.) with either 17β-E100 or Geni100 significantly reduce infarct size when the rabbits' hearts are submitted to 30-min CAO.
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文献和实验joya58 想请教大虾们一个问题，我准备定p38mapk的磷酸化抑制剂，看有SB202190和SB203580两种，文献上都有用，但是不知道有什么区别，该如何选择？ 还有从哪家公司购买比较好？calbiochem? 丁香通 建议到丁香通发布求购信息 1、信息可持续保留，不会像bbs帖子这样容易沉下去 2、发布求购信息，有机会赢取千元大奖，每月都有中奖机会，详见： 你求购
世霸总批发 SB1A01 SB1A01S SB1A02 SB1A02S SB1A03 SB1A03S SB1A01E SB1A01ES
徐州往事 我想做大鼠的p38MAPK的试验，需要用到SB203580干预，请问在大鼠中，SB203580的给药途径和剂量，最好能提供相关文献。谢谢 piaopiao5556 彼此彼此 ，我也做这个的 各个文献用量不一样，尤其关于大鼠的很少，看到一篇要用到50mg/kg。实验1小时前给药，哪来这么多钱啊？ 624980241 侧脑室 给药的量是 多少啊 ？ ldmin
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