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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
23593-75-1
- 规格：
10 mM * 1 mL/500 mg/1 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 500 mg | 产品价格： | ￥500.0 |
| 规格： | 1 g | 产品价格： | ￥744.0 |
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Clotrimazole
CAS No. : 23593-75-1
MCE 国际站：Clotrimazole
产品活性：Clotrimazole是咪唑衍生物，有抗真菌活性，是P450抑制剂。Clotrimazole 还具有抗菌活性。
研究领域：Anti-infection | Autophagy
作用靶点：Fungal | Bacterial | Autophagy | Antibiotic
In Vitro: Clotrimazole (brand name Canesten or Lotrimin) is an antifungal medication commonly used in the treatment of fungal infections (of both humans and other animals) such as vaginal yeast infections, oral thrush, and ringworm. It is also used to treat athlete's foot and jock itch.It is commonly available as an over-the-counter substance in various dosage forms, such as a cream, and also (especially in the case of ear infection) as a combination medicine. It is also available as a troche or throat lozenge (prescription only). For ear infection, it is often applied in liquid form, as ear drops.?The antimycotic drug clotrimazole inhibits the function of the gastric H,K-ATPase in a manner similar to that observed for the Na,K-ATPase. Because of the high hydrophobicity of the compound, the interaction between clotrimazole and the ion pump occurs at the membrane domain in the apolar core of the membrane. The enzymatic activity was inhibited with a half-saturating concentration of 5.2 microM. Various partial reactions of the pump cycle were analyzed with the electrochromic styryl dye RH421 that has been widely used to study the transport mechanism of P-type ATPases.
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文献和实验-450依赖性的14-α-去甲基酶，使14-α-甲基固醇蓄积，细胞膜麦角固醇不能合成，使细胞膜通透性改变，导致胞内重要物质丢失而使真菌死亡。本类药物在肝脏代谢，主要经胆汁排出，在肾功能不全时不需改变剂量。主要毒性为 贫血 、胃肠道反应、皮疹等。 1．克霉唑（clotrimazole）对大多数真菌具有抗菌作用，对深部真菌作用不及两性霉素B。口服吸收差，一次服3g的血药峰浓度仅1.29mg/L，t 1/2 为3.5～5.5小时。连续
-甲基固醇蓄积，细胞膜麦角固醇不能合成，使细胞膜通透性改变，导致胞内重要物质丢失而使真菌死亡。本类药物在肝脏代谢，主要经胆汁排出，在肾功能不全时不需改变剂量。主要毒性为 贫血 、胃肠道反应、皮疹等。 1．克霉唑（clotrimazole）对大多数真菌具有抗菌作用，对深部真菌作用不及两性霉素B。口服吸收差，一次服3g的血药峰浓度仅1.29mg/L，t 1/2 为3.5～5.5小时。连续给药由于肝药酶诱导作用可使血药浓度降低。不良
及毛巾均应用开水烫洗。 2．改变阴道酸碱度用2％～4％碳酸氢钠液冲洗阴道，造成不利于念珠菌生存的条件。 3．杀菌剂以碱性溶液冲洗后，选用下列药物：①克霉唑（clotrimazole）栓剂或片剂，每晚1次，每次1粒或1片，塞入阴道深部，连用7日；②达克宁（硝酸咪康唑miconazole）栓剂，每晚1粒塞入阴道，连用7日；③制霉菌素（nystatin）栓剂或片剂，每晚1次，每次1粒或1片（10万U），连用7～10日；④米可定阴道泡腾片，每晚1片，塞入阴道内，连用5日；⑤1％龙胆紫水溶
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