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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
330461-64-8
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥605.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥500.0 |
| 规格： | 10 mg | 产品价格： | ￥800.0 |
| 规格： | 25 mg | 产品价格： | ￥1600.0 |
| 规格： | 50 mg | 产品价格： | ￥2500.0 |
| 规格： | 100 mg | 产品价格： | ￥3800.0 |
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AK-1
CAS No. : 330461-64-8
MCE 国际站：AK-1
产品活性：AK-1是一种有效的，特异性的和细胞可渗透的SIRT2抑制剂，其 IC50 值为 12.5 μM。
研究领域：Cell Cycle/DNA Damage | Epigenetics
作用靶点：Sirtuin
In Vitro: AK-1 achieves significant neuroprotection in Huntington’s disease flies at 10 μM, improving the number of rhabdomeres from 5.2 to 5.6. AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor, with an IC50 of 12.5 μM. AK-1 treatment induces proteasomal degradation of the Snail transcription factor through inactivation of the NF-κB/CSN2 pathway. Reduction in the level of Snail results in upregulation of p21, leading to G1 arrest, slow proliferation, and slow wound-healing activity. The regulation of Snail-p21 axis by AK-1 also occurs in HT-29 colon cancer cells. Under hypoxic conditions, AK-1 increases the ubiquitination of HIF-1α in a VHL-dependent manner, leading to the degradation of HIF-1α via a proteasomal pathway. Downregulation of HIF-1α expression reduces its transcriptional activity and, eventually, reduces the expression of BNIP3, one of HIF-1 target genes, in AK-1-treated cells.
相关产品：Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Histone Modification Research Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Glutamine Metabolism Compound Library | Neuroprotective Compound Library | Highly Selective Inhibitors Library | Nicotinamide | Resveratrol | Selisistat | 3-TYP | Nicotinamide riboside chloride | Fisetin | OSS_128167 | Suramin sodium salt | SRT 1720 | UBCS039 | AGK2 | Sirtinol | SRT 2104 | SIRT7 inhibitor 97491 | Thiomyristoyl | Tenovin-6 | MC3482 | SirReal2 | Cambinol | SRT 2183 | Ganoderic acid D | SIRT5 inhibitor 1 | SRT 1460 | AK-7 | Agrimol B | CAY10602 | SIRT-IN-3 | ADTL-SA1215 | Perindopril erbumine
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文献和实验: AK-1, 1 ES-D, 1 G6PD, B GLO-I, 2 Me-2, 1-2 PGM1, 1-2 PGM3, 1 本文由丁香园论坛提供，想了解更多有用的、有意思的前沿资讯以及酷炫的实验方法的你，都可以成为师兄的好伙伴 师兄微信号：shixiongcoming
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