- ¥780 - 2200
- LMAI Bio
- LM-2570R
- 进口/国产
- 2026年01月08日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 Flow-Cyt=3μg/Test （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-2570R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
CD26
- 抗体名：
CD26抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
- 免疫原：
KLH conjugated synthetic peptide derived from human CD26:661-766/766
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 Flow-Cyt=3μg/Test （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
50ul 100ul 200ul
CD26抗体
| 英文名称 | CD26 |
| 中文名称 | CD26抗体 |
| 别 名 | ADCP2; DPPIV; Dipeptidyl peptidase 4; ADABP; ADCP 2; Adenosine deaminase complexing protein 2; CD 26; CD26; CD26 antigen 3; Dipeptidyl peptidase 4; Dipeptidyl peptidase iv; Dipeptidylpeptidase 4; Dipeptidylpeptidase IV; DPP 4; DPP IV; DPP4; Intestinal dipeptidyl peptidase; T cell activation antigen CD26; TP 103; TP103. |
 |
Specific References (2) | bs-2570R has been referenced in 2 publications. [IF=0.68] Lu Z, Qi L, Bo XJ, Liu GD, Wang JM, Li G. Expression of CD26 and CXCR4 in prostate carcinoma and its relationship with clinical parameters. CD26 and CXCR4 expression shows correlation with prostate cancer. J Res Med Sci 2013;18:647-52 Human. PubMed:24379839 [IF=5.99] Eckerle, Isabella. "Replicative Capacity of MERS Coronavirus in Livestock Cell Lines." Emerging Infectious Diseases 2014 Goat. PubMed:24457147 |
| 规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul 200ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 干细胞 细胞凋亡 细胞膜受体 细胞粘附分子 细胞表面分子 糖蛋白 淋巴细胞 t-淋巴细胞 b-淋巴细胞 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 Flow-Cyt=3μg/Test （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 84kDa |
| 细胞定位 | 细胞浆 细胞膜 细胞外基质 分泌型蛋白 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CD26:661-766/766 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Function: Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. Subcellular Location: Cell membrane. Apical cell membrane. Cell projection > invadopodium membrane. Cell projection > lamellipodium membrane. Cell junction. Membrane raft. Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids. Redistributed to membrane rafts in T-cell in a interleukin-12-dependent activation. Its interaction with CAV1 is necessary for its translocation to membrane rafts. Colocalized with PTPRC in membrane rafts. Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion. Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface and Secreted. Detected in the serum and the seminal fluid. Tissue Specificity: Expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at protein level). Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon. Post-translational modifications: The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing. N- and O-Glycosylated. Phosphorylated. Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells. Mannose 6-phosphorylation is induced during T-cell activation. Similarity: Belongs to the peptidase S9B family. DPPIV subfamily. SWISS: P27487 Gene ID: 1803 Database links: Entrez Gene: 1803 Human Entrez Gene: 13482 Mouse Entrez Gene: 25253 Rat Omim: 102720 Human SwissProt: P27487 Human SwissProt: P28843 Mouse SwissProt: P14740 Rat Unigene: 368912 Human Unigene: 1151 Mouse Unigene: 91364 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD26是细胞表面上一种氨基肽酶，具有丝氨酸蛋白酶活性，属于丝氨酸蛋白酶s9b家族,分布于多种细胞表面或游离于胞浆中，具有高度保守的蛋白水解酶活性. 还是一种细胞膜受体、共刺激分子，参与机体免疫调节、细胞迁移、细胞黏附和细胞凋亡. |
| 产品图片 |  Paraformaldehyde-fixed, paraffin embedded (Human melanoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD26) Polyclonal Antibody, Unconjugated (bs-2570R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.  Paraformaldehyde-fixed, paraffin embedded (rat intestine tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD26) Polyclonal Antibody, Unconjugated (bs-2570R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.  Blank control(blue): Raji (fixed with 2% paraformaldehyde (10 min)). Primary Antibody:Rabbit Anti-CD26 antibody(bs-2570R), Dilution: 3μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA. |
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文献和实验相关实验
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抗体的结构决定了其对应的功能，同一抗体的V区和C区的氨基酸组成和顺序不同，决定了其功能上的差异。V区和C区的组成和结构，决定了抗体的生物学功能。 图1：抗体的主要功能（图片来源：Abbas et al: Cellular and Molecular Immunology, 7e.) 1、特异性识别功能 抗体可以通过其结构上的可变区域与抗原结合，同时，具有极高的特异性。这种特异性识别功能可以使抗体识别和结合到感染的病原体，肿瘤细胞等不同种类的分子，帮助免疫系统识别并定位到这些分子，进而启动
在生命科学和医学基础研究中，或多或少都需要用到抗体。抗体的应用场景不同、标记物众多，且针对同一标记物市场上往往有多个抗体可供选择，那么，我们如何从成百万上千万种抗体中，挑选出我们想要的那支呢？ 在我们6月份的关于抗体的调研活动中，我们发现，大家更多的是去参考文献或专利中的材料和方法部分，这无疑很大程度上保证了抗体的有效性。其次有45%和34%的受访者会用到百度和谷歌，然而这两个搜索引擎覆盖面颇广，经常会出现抗体无关的搜索结果，而专业用于查找抗体的网站，大家却知之甚少。 因此，本次文章中
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CD26抗体
¥780 - 2200
