DLK1穿膜蛋白DLK1抗体

DLK1穿膜蛋白DLK1抗体

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  • ¥780 - 2200
  • LMAI Bio
  • LM-2423R
  • 进口/国产
  • 2025年07月11日
  • WB=1:500-2000 ELISA=1:500-1000 (石蜡切片需做抗原修复)
  • Rabbit
  • Human, Mouse, Rat, Pig, Rabbit, Sheep,
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    • 详细信息
    • 技术资料
    • 供应商

      上海联迈生物工程有限公司

    • 库存

      大量

    • 目录编号

      LM-2423R

    • 克隆性

      多克隆

    • 抗原来源

      Rabbit

    • 保质期

      1年

    • 抗体英文名

      DLK1

    • 抗体名

      穿膜蛋白DLK1抗体

    • 宿主

      Rabbit

    • 适应物种

      Human, Mouse, Rat, Pig, Rabbit, Sheep,

    • 免疫原

      KLH conjugated synthetic peptide derived from human DLK1:251-350/383 <Extracellular>

    • 亚型

      IgG

    • 形态

      Lyophilized or Liquid

    • 应用范围

      WB=1:500-2000 ELISA=1:500-1000 (石蜡切片需做抗原修复)

    • 浓度

      1mg/ml

    • 保存条件

      Store at -20 °C

    • 规格

      50ul  100ul  200ul

    DLK1穿膜蛋白DLK1抗体
    英文名称 DLK1
    中文名称 穿膜蛋白DLK1抗体
    别    名 Adipocyte differentiation inhibitor protein; Brevideltin; Delta like 1 homolog; Delta like homolog; Delta like protein; Delta1; DLK 1; DLK; DLK-1; Dlk1; DLK1_HUMAN; FA 1; FA1; Fetal antigen 1; pG2; Preadipocyte factor 1; Pref 1; Pref; Pref1; Pref-1; Protein delta homolog 1; Secredeltin; ZOG; Delta1; PREF1.  
    规格价格 50ul/780元 购买    100ul/1380元 购买    200ul/2200元 购买    大包装/询价
    说 明 书 50ul  100ul  200ul
    研究领域 肿瘤  神经生物学  信号转导  干细胞  转录调节因子  结合蛋白  细胞表面分子  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, Pig, Rabbit, Sheep, 
    产品应用 WB=1:500-2000 ELISA=1:500-1000 (石蜡切片需做抗原修复) 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 42kDa
    细胞定位 细胞膜 
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human DLK1:251-350/383 <Extracellular>
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    PubMed PubMed
    产品介绍 background:
    This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass. [provided by RefSeq, Mar 2010].

    Function:
    May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation.

    Subunit:
    Monomer.

    Subcellular Location:
    Membrane; Single-pass type I membrane protein.

    Tissue Specificity:
    Highly expressed in fetal liver, placenta, adult adrenal gland, brain, testis and ovary and, to a lesser degree, in adult kidney, muscle, thymus and heart.

    Post-translational modifications:
    N- and O-glycosylated.

    Similarity:
    Contains 6 EGF-like domains.

    SWISS:
    P80370

    Gene ID:
    8788

    Database links:

    Entrez Gene: 8788 Human

    Entrez Gene: 13386 Mouse

    Entrez Gene: 114587 Rat

    Omim: 176290 Human

    SwissProt: P80370 Human

    SwissProt: Q09163 Mouse

    Unigene: 533717 Human

    Unigene: 157069 Mouse

    Unigene: 14547 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

    穿膜蛋白DLK1又称肝癌相关基因,是表皮生长因子(EGF)家族的成员之一,其结构特征为蛋白的细胞外区域拥有在结构及氨基酸序列上与表皮生长因子高度同源的重复结构.DLK1可以抑制脂肪前体细胞向脂肪细胞分化,在正常神经内分泌细胞及其肿瘤细胞中表达, DLK1在神经内分泌轴中起着调控细胞生长分化的作用,同时DLK1在胚胎肝、造血干细胞及早期肌肉组织中均有表达。
    产品图片 DLK1穿膜蛋白DLK1抗体
    Sample: 
    HepG2(Human) Cell Lysate at 40 ug
    Primary: Anti-DLK1 (bs-2423R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 42 kD
    Observed band size: 42/65 kD

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