Robo4肿瘤血管内皮调节蛋白Robo4抗体

Robo4肿瘤血管内皮调节蛋白Robo4抗体

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  • ¥780 - 2200
  • LMAI Bio
  • LM-5795R
  • 进口/国产
  • 2025年11月25日
  • WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)
  • Rabbit
  • Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
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    • 详细信息
    • 技术资料
    • 供应商

      上海联迈生物工程有限公司

    • 库存

      大量

    • 目录编号

      LM-5795R

    • 克隆性

      多克隆

    • 抗原来源

      Rabbit

    • 保质期

      1年

    • 抗体英文名

      Robo4

    • 抗体名

      肿瘤血管内皮调节蛋白Robo4抗体

    • 宿主

      Rabbit

    • 适应物种

      Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,

    • 免疫原

      KLH conjugated synthetic peptide derived from human Robo4 (301-340aa):261-360/1007

    • 亚型

      IgG

    • 形态

      Lyophilized or Liquid

    • 应用范围

      WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复)

    • 浓度

      1mg/ml

    • 保存条件

      Store at -20 °C

    • 规格

      50ul  100ul  200ul

    Robo4肿瘤血管内皮调节蛋白Robo4抗体
    英文名称 Robo4
    中文名称 肿瘤血管内皮调节蛋白Robo4抗体
    别    名 Magic roundabout; MRB; Robo 4; Roundabout homolog 4; Roundabout homolog 4 magic roundabout; Roundabout homolog 4 Precursor.  
    规格价格 50ul/780元 购买    100ul/1380元 购买    200ul/2200元 购买    大包装/询价
    说 明 书 50ul  100ul  200ul
    研究领域 肿瘤  心血管  细胞生物  免疫学  神经生物学  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
    产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 108kDa
    细胞定位 细胞膜 
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human Robo4 (301-340aa):261-360/1007 
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    PubMed PubMed
    产品介绍 background:
    Robo4 is a vascular specific receptor that is a repulsive cue to migrating endothelial cells during vascular development. Guidance and patterning of axons are orchestrated by cell surface receptors and ligands that provide directional cues. Interactions between the Robo receptor and Slit ligand families of proteins initiate signaling cascades that repel axonal outgrowth. In contrast to known neuronal Robo family members, the arrangement of the extracellular domains of Robo4 diverges significantly from that of all other Robo family members. Robo4 is specifically expressed in the vascular endothelium during murine embryonic development; the only Robo family member expressed in primary endothelial cells. Robo4 also has a role in regulating the migration of endothelial cells during tumor angiogenesis.

    Function:
    Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit protein.

    Subunit:
    Interacts with SLIT2 and ENAH.

    Tissue Specificity:
    Specifically expressed in endothelial cells. Expressed at sites of angiogenesis in different tumor types.

    Similarity:
    Belongs to the immunoglobulin superfamily. ROBO family.
    Contains 2 fibronectin type-III domains.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

    SWISS:
    Q8WZ75

    Gene ID:
    54538

    Database links:
    UniProtKB/Swiss-Prot: Q8WZ75.1
    Gene ID: 54538(human)

    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

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