K63泛素链特异性的串联结合实体，生物素偶联Anti-K63

产品名称：K63泛素链特异性的串联结合实体，生物素偶联Anti-K63 TUBE,Biotin

产品货号：LSS-UM304

产品规格：50ug

产品描述：Tandem Ubiquitin Binding Entities (TUBEs) capitalize on the linkage of multiple ubiquitin interacting motifs (UIMs) to generate reagents with high affinity for polyubiquitin. Biotin K63-TUBE binds K63-linked polyubiquitin with a 1000 to 10,000-fold preference for K63 over other linkage types and provides a sensitive and cost-effective tool for determining the abundance of K63-linked polyubiquitin in the cell, or identifying the linkage-type associated with a particular protein of interest. Based on an engineered peptide developed by Sims et al., Biotin K63-TUBE consists of multiple ubiquitin interacting motifs separated by rigid linkers, presumably increasing its affinity to extended K63 polyubiquitin chains. Biotin K63-TUBE is useful for detection and characterization of K63-linked polyubiquitylated proteins by Far Western blotting, affinity purification from lysates and biological fluids, and in situ detection.

保存建议：K63泛素链特异性的串联结合实体，生物素偶联建议收到产品后置于-80℃保存。

背景资料：泛素蛋白（Ub）是存在于所有真核细胞中的高度保守的8kDa多肽，通过三种酶的顺序作用与靶蛋白中赖氨酸残基的ε-氨基缀合，E1Ub活化酶，E2偶联酶和E3连接酶。另外，Ub内的7个赖氨酸本身可以作为Ub受体，导致形成多聚泛素蛋白链。在这些K48和K63连接中有很好的特征。K48连接的多聚泛素化靶向用于蛋白酶体降解的蛋白质，而K63连接调节信号事件，受体内吞作用和免疫应答。其它赖氨酸的多聚泛素蛋白连接尚不显著，其生理作用仍然大部分未知。

点击：K63泛素链特异性的串联结合实体，生物素偶联Anti-K63 TUBE,Biotin查看更详细产品说明，更多应用、储存、价格、货期等信息请致电垂询中国区域授权总代理艾美捷科技有限公司。更多特色试剂盒、特色抗体以及特色试剂等产品评论，请点击查看每日生物评论网站。