沙利度胺，E3泛素连接酶抑制剂Thalidomide,con

Enzyme Inhibitor Screening by CE with an On-Column Immobilized Enzyme Microreactor Created by an Ionic Binding Technique

and thereafter determining the product of the enzyme-mediated reaction. Enzyme inhibition can be read out directly from the reduced peak area of product in comparison with that in the reference electropherogram obtained in the absence of any inhibitor.

A Screening Strategy for Trapping the Inactive Conformer of a Dimeric Enzyme with a Small Molecule Inhibitor

Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi’s sarcoma (KS), the most common cancer in AIDS patients. All herpesviruses express a conserved dimeric serine protease that is required for generating

A Conformationally Restricted -Strand HIV Protease Inhibitor

after the potent HIV protease inhibitor 2 , which together with a series of related derivatives was developed at Abbott Laboratories ( 11 ). This pseudopeptide contains a symmetrical diamino diol motif 8 (Fig. 2 ) flanked by Cbz-protected valine residues