- ¥780 - 2200
- LMAI Bio
- LM-1843R
- 进口/国产
- 2025年07月09日
- WB=1:500-2000 ELISA=1:500-1000 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-1843R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
LEF-1
- 抗体名：
淋巴增强因子-1抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit,
- 免疫原：
KLH conjugated synthetic peptide derived from human LEF-1:331-399/399
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
50ul 100ul 200ul
LEF-1淋巴增强因子-1抗体
| 英文名称 | LEF-1 |
| 中文名称 | 淋巴增强因子-1抗体 |
| 别 名 | lymphoid enhancing factor-1; Transcription factor T cell specific 1 alpha ; DKFZp586H0919; LEF 1; LEF1; Lymphoid enhancer binding factor 1; T cell specific transcription factor 1 alpha; TCF 1 alpha; TCF1 alpha; TCF1alpha; TCF1-alpha; LEF1_HUMAN; Lymphoid enhancer-binding factor 1; LEF-1; T cell-specific transcription factor 1-alpha. |
 |
Specific References (3) | bs-1843R has been referenced in 3 publications. [IF=2.76] Song, Honghua, et al. "The Regenerating Spinal Cord of Gecko Maintains Unaltered Expression of β-Catenin Following Tail Amputation." Journal of Molecular Neuroscience (2014): 1-10. WB ; PubMed:25178821 [IF=1.52] Wang, Kun, et al. "MiR-27a regulates Wnt/beta-catenin signaling through targeting SFRP1 in glioma." NeuroReport 26.12 (2015): 695-702. WB ; Human. PubMed:26164457 [IF=2.40] Xu, Wei, et al. "Resveratrol Attenuates Hyperoxia‐induced Oxidative Stress, Inflammation and Fibrosis and Suppresses Wnt/β‐catenin Signaling in Lungs of Neonatal Rats." Clinical and Experimental Pharmacology and Physiology(2015). WB ; Rat. PubMed:26174235 |
| 规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul 200ul |
| 研究领域 | 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 44kDa |
| 细胞定位 | 细胞核 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LEF-1:331-399/399 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]. Function: Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. Subunit: Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with EP300, TLE1 and PIASG (By similarity). Binds ALYREF/THOC4, MDFI and MDFIC. Interacts with NLK. Subcellular Location: Nucleus. Note=Found in nuclear bodies upon PIASG binding. Tissue Specificity: Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines. Post-translational modifications: Phosphorylated at Thr-155 and/or Ser-166 by NLK. Phosphorylation by NLK at these sites represses LEF1-mediated transcriptional activation of target genes of the canonical Wnt signaling pathway. Similarity: Belongs to the TCF/LEF family. Contains 1 HMG box DNA-binding domain. SWISS: Q9UJU2 Gene ID: 51176 Database links: Entrez Gene: 51176 Human Omim: 153245 Human SwissProt: Q9UJU2 Human Unigene: 726506 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. lef-1是淋巴增强因子/T-细胞因子(LEF/TCF)家族的成员之一,属于高迁移率组分蛋白家族。lef-1也是一个重要的转录因子，是Wnt信号通路的核心成分。 |
| 产品图片 |  Sample: Lymph nodes (Mouse) Lysate at 30 ug Primary: Anti- LEF-1 (bs-1843R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/10000 dilution Predicted band size: 44 kD Observed band size: 47 kD |
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文献和实验相关实验
wywdxfsh 在ncbi上查不到这个咚咚，只有转录因子 transcription factor 4 我做的小鼠的 freecell T细胞因子(TCF)/淋巴增强因子(LEF)是Wnt信号传导通路的主要信号分子。TCF/LEF家族包括LEF-1、TCF-1、 TCF-3、TCF-4。其中TCF-4是Wnt信号传导通路的一个重要的分子，并且在肿瘤的发生过程中起重要作用. SEE: http
买。 3、SpinSep® DM-M小鼠专用的淋巴细胞分离液与人用的密度不同，不能混用。 4、可订制的抗体包括：CD2，CD3，CD4，CD5，CD8，CD11b，CD45R，Gr-1，TER119，F4/80，Neutrophil (7-4)，Pan NK (DX5) 5、如果您有自己的大鼠抗小鼠IgG1抗体，并希望用SpinSep® 进行负选，您只需购买SpinSep® 密度粒子和小鼠淋巴细胞分离液。
（1）自制分型血清抗体：效价太低、亲和力不强，造成定型不准确。 （2）患者纤维蛋白原增高或为异常蛋白血症：如多发性骨髓瘤，巨球蛋白血症等，可产生缗线状假凝集。新生儿脐血中含有华顿胶或操作中使用了质量差的玻璃管（瓶），误认其脱下的胶状硅酸盐为串钱状凝集医|学教育网整理。 （3）患者输入了高分子血浆代用品或静脉注射造影剂等药物：可引起红细胞聚集，易误认为凝集。 （4）血清中可能存在的不规则抗体：如A2和A2B型患者血清内有抗A1抗体，能凝集A1红细胞。此外还有抗Ⅰ抗体
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LEF-1淋巴增强因子-1抗体
¥780 - 2200
