dPPA

dPPA

≥98% (HPLC)

别名:
12-Deoxyphorbol 13-phenylacetate 20-acetate, DOPPA
Empirical Formula (Hill Notation):
C₃₀H₃₆O₇

应用

dPPA/phorbol ester 12-deoxyphorbol 13-phenylacetate 20-acetate (DOPPA) may be used as a potent activator of PKC-β:

• to treat transfected HT-22 cells to promote phosphorylation of p66Shc 
• to treat HT-22 and B12 cells to study its effects on cell viability 
• to treat neurons and measure primary cortical neurons using the 2,5-diphenyl-2H-tetrazolium bromide (MTT) assay 

生化/生理作用

dPPA is a phorbol ester that selectively activates the β isotype of PKC. It is approximately 100-fold more potent for PKC-β than the α, γ or δ isotypes. PKC family members each have specific functions, but PKC-β and δ appear to share similar expression profiles, and both are involved in regulating apoptosis and B cell activation, thus dPPA is a useful tool in determining PKCβ specific signaling events.


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