ST14 antibody

ST14 antibody

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  • ¥1380 - 2200
  • 康朗生物
  • kl-5892R
  • 中国/美国/德国
  • 2025年11月12日
  • WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500
  • Rabbit
  • Human, Mouse, Rat, Rabbit,
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    • 详细信息
    • 技术资料
    • 供应商

      上海康朗生物科技有限公司

    • 库存

      大量

    • 目录编号

      kl-5892R

    • 克隆性

      多克隆

    • 抗原来源

      Rabbit

    • 保质期

      12个月

    • 抗体英文名

      ST14 antibody

    • 抗体名

      丝氨酸蛋白酶14/膜型丝氨酸蛋白酶1抗体

    • 宿主

      Rabbit

    • 适应物种

      Human, Mouse, Rat, Rabbit,

    • 免疫原

      KLH conjugated synthetic peptide derived from human ST14/MTSP1:651-750/855 <Extracellular>

    • 亚型

      IgG

    • 形态

      冻干粉或液体

    • 应用范围

      WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500

    • 浓度

      1mg/ml

    • 保存条件

      -20 °C

    • 规格

      100ul 200ul

    ST14 antibody
    中文名称 丝氨酸蛋白酶14/膜型丝氨酸蛋白酶1抗体
    别    名 Epithin; HAI; Matripase; Matriptase; Membrane type serine protease 1; Membrane type serine protease; Membrane-type serine protease 1; MT SP1; MT-SP1; MTSP 1; MTSP1; Prostamin; PRSS 14; PRSS14; Serine protease 14; Serine protease TADG 15; Serine protease TADG-15; Serine protease TADG15; SNC 19; SNC19; ST 14; ST14; ST14_HUMAN; Suppression of tumorigenicity 14 (colon carcinoma matriptase epithin); Suppression of tumorigenicity 14; Suppressor of tumorigenicity 14 protein; Suppressor of tumorigenicity protein 14; TADG 15; TADG15; TMPRSS14; Tumor associated differentially expressed gene 15 protein; Tumor-associated differentially-expressed gene 15 protein.  
    规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价
    说 明 书 100ul  200ul
    研究领域 肿瘤  细胞生物  免疫学  信号转导  激酶和磷酸酶  细胞骨架  细胞外基质  泛素  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, Rabbit, 
    产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 95kDa
    细胞定位 细胞膜 
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human ST14/MTSP1:651-750/855 <Extracellular>
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    PubMed PubMed
    产品介绍 background:
    MTSP1 is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.

    Function:
    Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. 

    Subunit:
    Interacts with CDCP1. May interact with TMEFF1. 

    Subcellular Location:
    Membrane; Single-pass type II membrane protein (Probable).

    DISEASE:
    Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:610765]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.

    Similarity:
    Belongs to the peptidase S1 family.
    Contains 2 CUB domains.
    Contains 4 LDL-receptor class A domains.
    Contains 1 peptidase S1 domain.

    SWISS:
    Q9Y5Y6

    Gene ID:
    6768

    Database links:

    Entrez Gene: 6768 Human

    Entrez Gene: 19143 Mouse

    Entrez Gene: 114093 Rat

    Omim: 606797 Human

    SwissProt: Q9Y5Y6 Human

    SwissProt: P56677 Mouse

    Unigene: 504315 Human

    Unigene: 243926 Mouse

    Unigene: 49170 Rat



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

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