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GNB1L G蛋白β样蛋白抗体

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  • ¥1380 - 2200
  • LMAI Bio
  • LM-13465R
  • 进口/国产
  • 2025年07月12日
  • ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
  • Rabbit
  • Human, Mouse, Rat, Dog, Horse, Zebrafish, 
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 供应商

      上海联迈生物工程有限公司

    • 库存

      大量

    • 目录编号

      LM-13465R

    • 克隆性

      多克隆

    • 抗原来源

      Rabbit

    • 保质期

      1年

    • 抗体英文名

      GNB1L

    • 抗体名

      G蛋白β样蛋白抗体

    • 宿主

      Rabbit

    • 适应物种

      Human, Mouse, Rat, Dog, Horse, Zebrafish, 

    • 免疫原

      KLH conjugated synthetic peptide derived from human GNB1L:101-200/327 

    • 亚型

      IgG

    • 形态

      Lyophilized or Liquid

    • 应用范围

      ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)

    • 浓度

      1mg/ml

    • 保存条件

      Store at -20 °C

    • 规格

      100ul  200ul

    GNB1L G蛋白β样蛋白抗体
    英文名称 GNB1L
    中文名称 G蛋白β样蛋白抗体
    别    名 DGCRK3; ESTM55; fb98e06; fj09d12; FKSG1; G-protein beta subunit-like protein; guanine nucleotide binding protein (G protein), beta polypeptide 1-like; guanine nucleotide binding protein beta-subunit-like polypeptide; GY2; KIAA1645; WDR14; WDVCF; wu:fb98e06; wu:fj09d12; zgc:55774.  
    规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价
    说 明 书 100ul  200ul
    研究领域 心血管  细胞生物  信号转导  G蛋白偶联受体  G蛋白信号  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Mouse, Rat, Dog, Horse, Zebrafish, 
    产品应用 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 36kDa
    细胞定位 细胞膜 
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human GNB1L:101-200/327 
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    PubMed PubMed
    产品介绍 background:
    This gene encodes a G-protein beta-subunit-like polypeptide which is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 6 WD repeats and is highly expressed in the heart. The gene maps to the region on chromosome 22q11, which is deleted in DiGeorge syndrome, trisomic in derivative 22 syndrome and tetrasomic in cat-eye syndrome. Therefore, this gene may contribute to the etiology of those disorders. Transcripts from this gene share exons with some transcripts from the C22orf29 gene. [provided by RefSeq, Jul 2008].

    Function:
    GNB1L is a G-protein beta-subunit-like polypeptide which is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 6 WD repeats and is highly expressed in the heart. Therefore, this gene may contribute to the etiology of those disorders.This gene encodes a G-protein beta-subunit-like polypeptide which is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 6 WD repeats and is highly expressed in the heart. The gene maps to the region on chromosome 22q11, which is deleted in DiGeorge syndrome, trisomic in derivative 22 syndrome and tetrasomic in cat-eye syndrome. Therefore, this gene may contribute to the etiology of those disorders. 

    Tissue Specificity:
    Ubiquitous. Highly expressed in heart, liver, skeletal muscle, kidney, spleen, thymus and pancreas. Detected at low levels in lung, placenta and brain. 

    Similarity:
    Contains 6 WD repeats. 

    SWISS:
    Q9BYB4

    Gene ID:
    54584

    Database links:

    Entrez Gene: 54584 Human

    Entrez Gene: 13972 Mouse

    Entrez Gene: 406796 Zebrafish

    Omim: 610778 Human

    SwissProt: Q9BYB4 Human

    SwissProt: Q9EQ15 Mouse

    Unigene: 105642 Human

    Unigene: 236139 Mouse

    Unigene: 115426 Zebrafish



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

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    图标文献和实验
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    • 小鼠抵抗素分子β (RELM-β)酶联免疫分析(ELISA)

      小鼠抵抗素分子β (RELM- β ) 酶联免疫 分析( ELISA ) 试剂 盒使用说明书 本试剂仅供研究使用 目的:本试剂盒用于测定小鼠血清,血浆及相关液体样本中 抵抗素分子β (RELM-β) 含量。 实验原理 : 本试剂盒应用双抗体夹心法测定 标本 中 小鼠抵抗素分子β (RELM- β ) 水平。用纯化的 小鼠抵抗素分子β (RELM- β ) 抗体包被微孔板,制成固相抗体,往包被单抗的微孔中依次加入 抵抗素分子

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    • Science 背靠背!施一公、黄志伟团队同日揭开 B 细胞受体复合物的神秘面纱

      受体时候,观察到了 IgM 的单体状态。为什么会出现这一状态呢? 研究人员通过进一部分的结构分析发现,Igα 的 Ig 结构域和膜结合的 IgM-Cμ4 完全吻合。B 细胞受体的激活的过程,也是其逐渐多聚化的过程,而当 B 细胞受体静息状态下的时候,因为 Igα/β 的 Ig 结构域与 Cμ4 或 Cγ3 结合,这就导致了在空间上隔挡了 mIg 多聚化,使得其出于单体状态,而当抗原结合后,会对 Fab 结构域潜在施加一定的机械力,从而引发 mIg_Fc 的构象改变,进一步的将蛋白的寡聚体界面暴露

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