- ¥1380 - 2200
- LMAI Bio
- LM-12431R
- 进口/国产
- 2025年07月14日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Cow, Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-12431R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
DOCK2
- 抗体名：
细胞质分裂付出蛋白2抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Cow, Sheep,
- 免疫原：
KLH conjugated synthetic peptide derived from human DOCK2:451-550/1830
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | DOCK2 |
| 中文名称 | 细胞质分裂付出蛋白2抗体 |
| 别 名 | Dedicator of cyto kinesis 2; Dedicator of cytokinesis 2; Dedicator of cytokinesis protein 2; DOCK 2; FLJ46592; KIAA0209; DOCK2_HUMAN. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 干细胞 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Sheep, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 212kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DOCK2:451-550/1830 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: The DOCK2 gene encodes dedicator of cytokinesis 2 (DOCK 2), a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis. DOCK 2 participates in the cytoskeletal rearrangements that are required for lymphocyte migration in response of chemokines. This peripheral membrane protein activates Rac 1 and Rac 2 small GTPases, while presumably acting as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. DOCK 2 may also participate in IL-2 transcriptional activation through the activation of Rac 2. DOCK 2 contains one DHR-1 (CZH-1) domain, one DHR-2 (CZH-2) domain and one SH3 domain. The DHR-2 domain is a putative GEF activity mediator. The DOCK 2 protein also co-localizes with F-Actin, and demonstrates expression in several human tissues, with the highest levels observed in peripheral blood leukocytes, thymus, spleen and liver. Function: DOCK2 (dedicator of cytokinesis 2) is a hematopoietic cell-specific protein that participates in the cytoskeletal rearrangements required for lymphocyte migration in response to chemokines. DOCK2 activates the small GTPases RAC1 and RAC2 and may also be involved in IL2 transcriptional activation via the activation of RAC2. Subunit: Homodimer (Probable). Interacts with RAC1 and RAC2. Interacts with CRKL and VAV. Interacts with CD3Z. Subcellular Location: Intracytoplasmic membrane. Peripheral membrane protein. Note=Colocalizes with F-actin. Tissue Specificity: Specifically expressed in hematopoietic cells. Highly expressed in peripheral blood leukocytes, and expressed at intermediate level in thymus and spleen. Expressed at very low level in the small intestine and colon. Similarity: Belongs to the DOCK family. Contains 1 DHR-1 domain. Contains 1 DHR-2 domain. Contains 1 SH3 domain. SWISS: Q92608 Gene ID: 1794 Database links: Entrez Gene: 1794 Human Entrez Gene: 94176 Mouse Entrez Gene: 360509 Rat Omim: 603122 Human SwissProt: Q92608 Human SwissProt: Q8C3J5 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验核分裂 nuclear division，karyokinesis，mitosis
指细胞核的分裂。细胞分裂通常是核先分裂，然后以细胞质分裂而告完成。 karyokinesis（希腊语 karion=核， kinesis=运动）一词为 W． Schleicher（ 1878年）所创造，目前欧洲仍经常使用。核分裂可分为有丝分裂和无丝分裂，但无丝分裂多为极特殊的病态现象和退化现象，所以习惯上多将 mitosis（有丝分裂）作为核分裂的同义词来使用。核分裂有体细胞核分裂（ somatic nuclear division）及减数核分裂（ meiotic
绿藻门、接合藻纲、水绵科、水绵属植物。藻体是由 1列圆柱状细胞连成的不分枝的丝状体。由于藻体表面有较多的果胶质，所以用手触摸时颇觉粘滑。在显微镜下，可见每个细胞中有 1至多条带状叶缘体，呈螺旋状绕生于紧贴细胞壁内方的细胞质中，在叶绿体上有 1列蛋白核。细胞中央有 1个大液泡。 1个细胞核位于液泡中央的一团细胞质中。核周围的细胞质和四周紧贴细胞壁的细胞质之间，有多条呈放射状的胞质丝相连。生殖方式通常可见营养繁殖和有性生殖两种类型。营养繁殖时，为丝状体受到机械损伤或其他原因，断裂成若干短丝
绿藻门、团藻目、衣藻科中的衣藻属。藻体为单细胞，球形、卵形或椭圆形，细胞前端有 2条等长的鞭毛，藻体借鞭毛的摆动而游动。细胞质中多具 1个大形杯状叶绿体（也有的为“ H”形或星芒状，或片状），在叶绿体内靠细胞前部有 1个红色眼点，有感光作用。 1个细胞核，存在于杯状叶绿体凹入部分的细胞质中。在叶绿体的基部通常有 1个大而明显的蛋白核，其表面由聚集的淀粉形成的淀粉鞘。此外，在 2条鞭毛的基部通常还有 2个伸缩泡。生殖方式有无性和有性生殖两种类型。环境适宜时多连续进行无性生殖。无性生殖时
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