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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
23146-22-7
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥545.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥496.0 |
| 规格： | 10 mg | 产品价格： | ￥630.0 |
| 规格： | 25 mg | 产品价格： | ￥1184.0 |
| 规格： | 50 mg | 产品价格： | ￥1960.0 |
| 规格： | 100 mg | 产品价格： | ￥3220.0 |
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IQ-1S free acid
CAS No. : 23146-22-7
MCE 国际站：IQ-1S free acid
产品活性：IQ-1S free acid 是一种 NF-κB/激活蛋白1 (AP-1) 抑制剂，IC50 为 2.3±0.41 μM。IQ-1S free acid 对三种 JNK 都具有高的结合亲和力 (Kd 值)，对 JNK3，JNK1 和 JNK2 的 Kd 值分别为 100 nM，240 nM 和 360 nM。
研究领域：MAPK/ERK Pathway
作用靶点：JNK
In Vitro: Compound IQ-1S is a potent, noncytotoxic inhibitor of pro-inflammatory cytokine [interleukin (IL)-1α, IL-1β, IL-6, IL-10, tumor necrosis factor (TNF)-α, interferon-γ, and granulocyte-macrophage colony-stimulating factor] and nitric oxide production by human and murine monocyte/macrophages. The effect of IQ-1S is evaluated on LPS-induced cytokine production in human PBMCs. Among the 12 cytokines analyzed, LPS (200 ng/mL) consistently induces five (IL-1α, IL-1β, IL-6, IL-10, and TNF-α) in PBMCs compared with DMSO-treated control cells. Production of all of these cytokines is significantly inhibited by 20 μM IQ-1S. Among them, TNF-α production is inhibited completely by IQ-1 (>99%), the levels of IL-1α, IL-1β, and IL-10 are decreased by 85%, and IL-6 production is decreased by 33%.
In Vivo: When mice are dosed with 12.5 and 30 mg/kg IQ-1S (The sodium salt of IQ-1S) i.p., the serum exposure of the compound is also good, with AUC0-12h values of 2.9 and 7.4 μM/h, respectively.
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文献和实验Phosphoamino acid analysis:Mark Kamps's method
the pH. There have been occasional problems with badly smeared PAAs during electrophoresis at pH 3.5.Something seems to leach out of the wicks and make the PAAs relatively insoluble.Tony thinks it is aluminum.Bart thinks that it's calcium.In any case
Phosphoamino acid analysis:Mark Kamps method
Phosphoamino acid analysis:Mark Kamps's method 1. Label your protein with 32Pi. Then subject the protein to SDS polyacrylamide gel electrophoresis and transfer your gel-fractionated protein to Immobilon-P .
Phosphoamino acid analysis:Mark Kamps method
Phosphoamino acid analysis:Mark Kamps's method 1. Label your protein with 32Pi. Then subject the protein to SDS polyacrylamide gel electrophoresis and transfer your gel-fractionated protein to Immobilon-P .
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