- ¥1380 - 2200
- LMAI Bio
- LM-11274R
- 进口/国产
- 2025年07月12日
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-11274R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
Complement C4 / C4a
- 抗体名：
过敏毒素C4/补体C4抗体
- 宿主：
Rabbit
- 适应物种：
Human
- 免疫原：
KLH conjugated synthetic peptide derived from human Complement C4 C4a anaphylatoxin or complement C4 alpha chain:701-800/1744
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | Complement C4 / C4a |
| 中文名称 | 过敏毒素C4/补体C4抗体 |
| 别 名 | C4a anaphylatoxin; Complement C4-A alpha chain; complement C4-A proprotein; Acidic C4; Acidic complement C4; Basic C4; Basic complement C4; C4 Anaphylatoxin; C4 complement C4d region; complement C4 alpha chain; C4A; C4A13; C4A2; C4A3; C4A4; C4A6; C4A91; C4B; C4B1; C4B12; C4B2; C4B3; C4B5; C4F; C4S; CH; Chido form of C4; CO4; Complement C4 A; Complement C4 B; Complement C4B; Complement component 4A (Rodgers blood group); Complement component 4A; Complement component 4B (Childo blood group); Complement component 4B; Complement component C4B; CPAMD2; CPAMD3. RG; Rodgers Form Of C4. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 8/84/190kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Complement C4 C4a anaphylatoxin or complement C4 alpha chain:701-800/1744 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]. Function: C4 plays a central role in the activation of the classical pathway of the complement system. It is processed by activated C1 which removes from the alpha chain the C4a anaphylatoxin. Subunit: This protein is synthesized as a single-chain precursor and, prior to secretion, is enzymatically cleaved to form a trimer of non-identical chains (alpha, beta and gamma). Subcellular Location: Secreted. DISEASE: Defects in C4A are the cause of complement component 4A deficiency (C4AD). A rare defect of the complement classical pathway associated with the development of autoimmune disorders, mainly systemic lupus with or without associated glomerulonephritis. Similarity: Contains 1 anaphylatoxin-like domain. Contains 1 NTR domain. SWISS: P0C0L4 Gene ID: 720 Database links: Entrez Gene: 100293534 Human Entrez Gene: 100507685 Human Entrez Gene: 720 Human Entrez Gene: 721 Human Omim: 120810 Human SwissProt: P0C0L4 Human SwissProt: P0C0L5 Human Unigene: 534847 Human Unigene: 720022 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验Complement C4 Protein and DNA Typing Methods
Complement C4 is the only component coded for by two nearly identical isotypic genes, C4A and C4B. The C4 genes are located tandemly arranged each with a steroid 21-hydroxylase (CYP21) gene at its 3′ end, together with the genes for C2
Human Complement Components C4A and C4B Genetic Diversities: Complex Genotypes and Phenotypes
methods that can accurately determine the genotypes and phenotypes of human complement components C4A and C4B. Specifically, they allow investigators to determine how many C4 genes are present in a diploid genome of a human subject and to quantify
Molecular Analysis of Complement Component C4 Gene Copy Number
isotypes (C4A and C4B) may also lead to susceptibility to autoimmune disease. Therefore, in subjects with autoimmune disease, a low serum C4 level may be due to ongoing disease activity associated with complement activation and consumption
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