- ¥1580
- 康朗生物
- kl-2367R
- 中国/美国/德国
- 2025年07月14日
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=0.2μg/Test IF=1:100-500
- Rabbit
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海康朗生物科技有限公司
- 库存：
大量
- 目录编号：
kl-2367R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
12个月
- 抗体英文名：
ganglioside GM1 antibody
- 抗体名：
神经节苷酯抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
- 免疫原：
KLH conjugated ganglioside GM1 purified from bovine:
- 亚型：
IgG
- 形态：
冻干粉或液体
- 应用范围：
ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=0.2μg/Test IF=1:100-500
- 浓度：
1mg/ml
- 保存条件：
-20 °C
- 规格：
100ul
| 中文名称 | 神经节苷酯抗体 |
| 别 名 | GM1 ganglioside; Monosialoanglioside; ganglioside GM1. |
| 规格价格 | 100ul/1580元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 药物与化合物抗体 |
| 研究领域 | 细胞生物 免疫学 神经生物学 细胞表面分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, |
| 产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=0.2μg/Test IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 1.57kDa |
| 细胞定位 | 细胞浆 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated ganglioside GM1 purified from bovine: |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: A member of the family of glycosphingolipids, monosialoanglioside acts as a receptor and antigen for cholera. GM1 ganglioside, one of the glycosphingolipids widely distributed in all tissues, occurs in highest concentrations in the central nervous system (CNS). It is primarily located in the outer surface of the mammalian cell's plasma membrane and in synaptic membranes of the CNS. GM1 ganglioside modulates a number of cell surface and receptor activities as well as neuronal differentiation and development, protein phosphorilation and synaptic function. Subcellular Location: Plasma membrane SWISS: N/A CAS: N/A Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 含有唾液酸的鞘脂类。克伦克（E.Klenk，1935）首先发现在患Tay－sachs病（泰萨氏幼年型黑白痴病）的小儿脑中有蓄积（Tag－Sachs gangli-oside），在脑灰白质中含量很多，所以对这类糖脂命名为神经节苷脂。已知糖部分是由己糖、氨基糖、唾液酸组成的脑神经节苷脂有8种以上。由山川民夫（1951）在马血球基质中找到的非神经系统的神经节苷脂——主要是血苷脂[hematoside，结构为神经酰胺（1←1β）GLc（4←1β）Gal（3←2α）唾液酸]。神经节苷脂较多地存在于细胞膜，以其与膜功能的关系被引起重视。破伤风菌和霍乱菌的外毒素可与特定的神经节苷脂分子特异性结合。在水和有机溶剂中可溶。在水中是以数百万个分子聚合的微团状态存在。 神经节苷脂对神经再生有重大促进作用。加拿大金爵集团脑科学研究室首席科学家Gatte Walker博士进一步研究发现，神经生长因子（NGF）和神经节苷脂（GM）是脑神经再生发育必需物质，GM介导NGF数十倍增强其活性，形成新的丰富的神经网络，修复并促使脑神经再次发育。 GM能够介导神经生长因子NGF促进脑神经细胞再生，表现出良好的生物效应。——《西安交通医科大学学报》。 |
| 产品图片 |  Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-GM1(GS) Polyclonal Antibody, Unconjugated(bs-2367R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining  Blank control:RSC96 (blue). Primary Antibody: Rabbit Anti-ganglioside GM1/AF647 Conjugated antibody (bs-2367R-AF647), Dilution: 0.2μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG/AF647(orange) ,used under the same conditions. |
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文献和实验cell destruction by effector cells with Fc receptors such as natural killer (NK) cells and macrophages. These cells recognize the mAb binding to the tumor cells and mediate antibody-dependent cellular cytotoxicity (ADCC). Enhanced ADCC is mediated
Immunohistochemistry using Anti-Ganglioside Antibodies
, T., Terashima,T., and Tai, T.(1993) Generation of a monoclonal antibody specific for ganglioside GM4: evidence for GM4 expression on astrocytes in chicken cerebellum. J. Biochem.(Tokyo), 114 :5-8 3) Kotani, M., Kawashima, I., Ozawa, H., Ogura
人抗神经节苷脂抗体(GM1 IgG)ELISA试剂盒 说明书
上海西唐生物科技有限公司 021-55229872, 65333639 www.westang.com 人抗神经节苷脂抗体 (GM1 IgG)ELISA 试剂盒 ( 用于血清、血浆、细胞培养上清液和生物体液内 ) 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗人 GM1 IgG单抗包被于酶标板上，标准品和样品中的 GM1 IgG与单抗结合，加入生物素化的抗人
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