Exendin-4

性质
Related Categories    Cytokines Growth Factors and Hormones (Obesity), Cytokines, Growth Factors and Hormones, Exendin, GLP-1 Receptor Ligands, Hormones,
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assay      ≥97%
storage temp.      −20°C
Gene Information      human ... GLP1R(2740)
产品描述
Amino Acid Sequence
His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
Other Notes
Originally isolated from Heloderma suspectum (Gila monster lizard) venom.
Lyophilized from 0.1% TFA in H2O
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
Application
Exendin-4 has been used for the treatment of ob/ob mouse model to determine the glucose and insulin concentrations and homeostasis model of assessment (HOMA),[4] and for the determination of nuclear factor-κΒ (NF-κB) p65 level in macrophages treated with exendin-4.[5]
Biochem/physiol Actions
Exendin-4 mimics the activity of mammalian incretin hormone glucagon-like peptide 1 (GLP-1), and thus, functions in the control of glucose. This includes the secretion of insulin in a glucose dependent manner, negative regulation of high glucagon secretion, and increased duration of stomach emptying. In type 2 diabetes patients, this peptide can be administered subcutaneously for glycemic control, when metformin is unable to produce adequate results.[2] It promotes the neogeneration and proliferation of β-cells, and thus aids in the regeneration of pancreas.[3] It acts as a ligand to exendin receptor, and leads to an elevation of acinar cell cAMP levels.[1]
General description
Exendin-4 is an incretin mimetic peptide, which is composed of 39 amino acids.[2] It is an analog of glucagon-like peptide 1 (GLP-1), and an insulinotropic agent, with a long half-life.[3] It was originally isolated from the venom of Gila monster lizard called Heloderma suspectum.[1]