特别声明:本产品及我公司所售其他产品均为科研类试剂产品,严禁用于药物、医疗及其他非科研用途。
北京百奥莱博专业生产销*(代"售")JN0468型重组人肿瘤坏死因子α(N端His标签)哪里卖,我公司供应的分子生物学试剂品类齐全,且具有优势价格,欢迎新老客户垂询订购。
名称:JN0468型重组人肿瘤坏死因子α(N端His标签)哪里卖
编号:JN0468
规格:10μg|50μg|500μg|1mg
产地:国产|进口
英文名:Recombinant Human Tumor Necrosis Factor alpha
本品由我们的大肠杆菌表达系统制备而成,目的基因编码的Gly57-Leu233在N端含有His标签。
TNF-alpha质量控制:>95%(还原性SDS-PAGE)
TNF-alpha制剂:冻干品
TNF-alpha保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
TNF-alpha复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于TNF-alpha:
Tumor Necrosis Factor-α (TNF-α) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressing CD4 secrete TNF-α while cells that express CD8 secrete little or no TNF-α. Synthesis of TNF-α can be induced by many different stimuli including interferons, IL2, and GM-CSF. The clinical use of the potent anti-tumor activity of TNF-α has been limited by the proinflammatory side effects such as fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF-α mutants with low systemic toxicity has been of intense pharmacological interest. Human TNF-α that binds to murine TNF-R55 but not murine TNF-R7, exhibits retained anti-tumor activity and reduced systemic toxicity in mice comp*(代"a")red with murine TNF-α, which binds to both murine TNF receptors. Based on these results, many TNF-α mutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumor cell lines in vitro and have exhibited lower systemic toxicity in vivo. Recombinant Human TNF-α High Active Mutant differs from the wild-type by amino acid subsitution of amino acids 1-7 with Arg8, Lys9, Arg10 and Phe157. This mutant form has been shown to have increased activity with less inflammatory side effects in vivo.
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JN0468型重组人肿瘤坏死因子α(N端His标签)哪里卖关键词:N端His标签,重组肿瘤坏死因子α,重组人肿瘤坏死因子α蛋白,JN0468
·重组人泛素结合酶E2-B(UBCE2B)
编号:JN0965
英文名称:Recombinant Human Ubiquitin-Conjugating Enzyme E2 B
规格:10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成,目的基因编码的Met1-Ser152表达纯化得来。
UBE2B质量控制:>95%(还原性SDS-PAGE)
UBE2B制剂:液体
UBE2B保存:收到货后请置于-20℃,可保存6个月,避免反复冻融。
关于UBE2B:
Ubiquitin-Conjugating Enzyme E2 B (UBE2B) belongs to the ubiquitin-conjugating enzyme family. UBE2B can catalyze the covalent attachment of ubiquitin to other proteins, and is essential for the multi-ubiquitination and degradation of N-end rule substrates. UBE2B is indispensability for postreplication repair of UV-damaged DNA and may be involved in neurite outgrowth.Additionally, UBE2B may have a role in sepsis-induced muscle protein proteolysis and cancer-induced cachexia.
JN0468型重组人肿瘤坏死因子α(N端His标签)哪里卖关键词:N端His标签,重组肿瘤坏死因子α,重组人肿瘤坏死因子α蛋白,JN0468
·重组小鼠脂肪组织特异分泌因子(Resistin)(RETN)
编号:JN1359
英文名称:Recombinant Mouse Adipose tissue-specific secretory factor
规格:10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Ser21-Ser114在C端含有His标签。
Resistin/RETN质量控制:>95%(还原性SDS-PAGE)
Resistin/RETN制剂:冻干品
Resistin/RETN保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
Resistin/RETN复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于Resistin/RETN:
Resistin is a cysteine-rich adipose-derived peptide hormone, which belongs to the resistin/FIZZ family.Resistin has been shown to cause high levels of bad cholesterol (low-density lipoprotein or LDL), increasing the risk of heart disease, resistin increases the production of LDL in human liver cells and also degrades LDL receptors in the liver. As a result, the liver is less able to clear bad cholesterol from the body. Resistin accelerates the accumulation of LDL in arteries, increasing the risk of heart disease, resistin adversely imp*(代"a")cts the effects of statins, the main cholesterol-reducing drug used in the treatment and prevention of cardiovascular disease.
北京百莱博科技有限公司专业生产供应销*(代"售")生物试剂、化学试剂、抗原抗体、血清血浆、Elisa试剂盒,更多试剂产品需求,欢迎来电咨询选购JN0468型重组人肿瘤坏死因子α(N端His标签)哪里卖。