重组人Mesothelin(间皮素)大量库存促销

特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、医疗及其他非科研用途。

北京百奥莱博专业生产供应重组人Mesothelin(间皮素)大量库存促销，我公司销*(代"售")全品类的分子生物学试剂，价格优惠，欢迎广大科研工作者垂询订购。

名称：重组人Mesothelin(间皮素)大量库存促销
编号：JN1582
英文名：Recombinant Human Mesothelin
产地：国产|进口
品牌：百奥莱博
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Glu296-Ser598在C端带有Fc标签。

Mesothelin质量控制：＞95%(还原性SDS-PAGE)

Mesothelin制剂：冻干品

Mesothelin保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

Mesothelin复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于Mesothelin：
Mesothelin is a cell surface glycoprotein whose expression is limited to mesothelial cells of the serosa (pleura, pericardium, and peritoneum) and epithelial cells of the trachea, tonsils, fallopian tube, and kidneys. Mesothelin plays an important role in cell survival, proliferation, migration, invasion, tumor progression, and resistance to chemotherapy. The overexpression of mesothelin can activate NF-κB and signal transducer and activator of transcription 3 (Stat3), inhibit apoptotic signaling and TNF-α-induced apoptosis, and accelerate the G1–S transition. Mesothelin is also found overexpressed in various cancers, including malignant mesothelioma, pancreatic or ovarian carcinoma, sarcomas and in some gastrointestinal or pulmonary carcinomas. As a result of its limited expression in normal tissues, mesothelin has been reported as an ideal tumor-associated marker for the development of targeted therapy.

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重组人Mesothelin(间皮素)大量库存促销关键词：重组人Mesothelin,重组人间皮素,重组Mesothelin,JN1582,重组人Mesothelin蛋白


·重组小鼠Legumain(天冬酰胺肽链内切酶)(天冬*酸内肽酶)
编号：JN1806
英文名称：Recombinant Mouse Legumain/Asparaginyl Endopeptidase
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Val18-Tyr435在C端含有His标签。

Legumain质量控制：＞95%(还原性SDS-PAGE)

Legumain制剂：液体

Legumain保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于Legumain：
Mouse Legumain,also known as LGMN, is a cysteine protease belonging to peptidase family C13 and is expressed in kidney and placenta abundantly. LGMN has a strict specificity for hydrolysis of asparaginyl bonds. It can also cleave aspartyl bonds slowly, especially under acidic conditions. The mammalian legumain is involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. It plays a role in the regulation of cell proliferation via its role in EGFR degradation. Legumain deficiency causes the accumulation of pro-Cathepsins B, H and L, another group of lysosomal cysteine proteases. Overexpression of Legumain in tumors is significant for invasion/metastasis. Mammalian legumain is inhibited by iodoacetamide and maleimides. Legumain activation appears to be autocatalytic and can be triggered by acidic pH.



重组人Mesothelin(间皮素)大量库存促销关键词：重组人Mesothelin,重组人间皮素,重组Mesothelin,JN1582,重组人Mesothelin蛋白


·重组人THOP1
编号：JN1668
英文名称：Recombinant Human Thimet Oligopeptidase
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Lys2-Cys689在C端含有His标签。

THOP1质量控制：＞95%(还原性SDS-PAGE)

THOP1制剂：液体

THOP1保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于THOP1：
Thimet Oligopeptidase (THOP1) belongs to the peptidase M3 family which includes neurolysin and mitochondrial intermediate peptidase. THOP1 is located in Cytoplasm. THOP1 is widely expressed in human tissues and can detected in different subcellular locations. THOP1 is preferential cleavage for bonds with hydrophobic residues at P1, P2 and P3 and a small residue at P1 in substrates of 5 to 15 residues. THOP1 is involved in the metabolism of neuropeptides under 20 amino acid residues and degradation of cytoplasmic peptide. In addition, THOP1 also can degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.

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