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- 详细信息
- 文献和实验
- 技术资料
- 库存:
329
- 英文名:
Recombinant Human Hepatocyte Cell Adhesion Molecule
- 保质期:
长期
- 供应商:
北京百奥莱博科技有限公司
- 保存条件:
冻干蛋白置于-20℃
特别声明:本产品及我公司所售其他产品均为科研类试剂产品,严禁用于药物、医疗及其他非科研用途。
北京百奥莱博专注于生命科学和生物技术领域,致力于为客户提供包括重组人肝细胞粘附分子(HEPACAM)现货价格在内的一系列分子生物学试剂产品,并提供一系列相关的技术服务。
名称:重组人肝细胞粘附分子(HEPACAM)现货价格
产地:国产|进口
品牌:百奥莱博
英文名:Recombinant Human Hepatocyte Cell Adhesion Molecule
规格:10μg|50μg|500μg|1mg
编号:JN0606
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Val34-Ser240在C端含有His标签。
HEPACAM质量控制:>95%(还原性SDS-PAGE)
HEPACAM制剂:冻干品
HEPACAM保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
HEPACAM复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于HEPACAM:
Hepatocyte Cell Adhesion Molecule (HEPACAM) is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. HEPACAM includes a signal sequence (amino acid 1-33), an extracellular region (amino acid 34-240) with one Ig-like C2-type domain and one Ig-like V-type domain, a transmembrane segment (amino acid 241-261), and a cytoplasmic domain (amino acid 262 - 416). The cytoplasmic domain plays an important role in regulation of cell-matrix adhesion and cell motility. HEPACAM acts as a homodimer and dimer formation occurs predominantly through cis interactions on the cell surface. HEPACAM is involved in cell motility and cell-matrix interactions. The expression of this gene is down-regulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene.
关于重组人肝细胞粘附分子(HEPACAM)现货价格的更详细说明,请致电我公司咨询,我们将以最饱满的热情为您提供解答,此外,我公司专业供应下列产品:
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二乙三胺五乙酸 N-Acetylneuraminic Acid Aldolase 67-43-6
ARB12436 大鼠骨形成蛋白6(BMP-6)Elisa定量检测 Rat bone morphogenetic protein 6,bmp-6 ELISA KIT
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PY01-131 烟酰胺(VPP) 25克
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重组人肝细胞粘附分子(HEPACAM)现货价格关键词:重组肝细胞粘附分子,JN0606,重组人肝细胞粘附分子,重组人肝细胞粘附分子蛋白,重组人HEPACAM
·重组人氧化型低密度脂蛋白受体1(OLR1)
编号:JN0607
英文名称:Recombinant Human Oxidized Low-Density Lipoprotein Receptor 1
规格:10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Ser61-Gln273在C端含有His标签。
OLR1质量控制:>95%(还原性SDS-PAGE)
OLR1制剂:冻干品
OLR1保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
OLR1复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于OLR1:
Oxidized Low-Density Lipoprotein Receptor 1 (Ox-LDL Receptor 1) is a secreted, single-pass type II membrane protein which belongs to the C-type lectin superfamily. Ox-LDL Receptor 1 is expressed at high levels in endothelial cells and vascular-rich organs such as placenta, lung, liver, brain, aortic intima, bone marrow, spinal cord and substantia nigra. The expression of Ox-LDL Receptor 1 is induced by inflammatory cytokines such as TNF, IFNG and IL6 by pathological conditions, such as hyperlipidemia, hypertension and diabetes mellitus. Ox-LDL Receptor 1 mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (OxLDL) by vascular endothelial cells. Ox-LDL Receptor 1 association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. Ox-LDL Receptor 1 also binds to oxLDL, which acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. It also participates in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation.
重组人肝细胞粘附分子(HEPACAM)现货价格关键词:重组肝细胞粘附分子,JN0606,重组人肝细胞粘附分子,重组人肝细胞粘附分子蛋白,重组人HEPACAM
·重组人淋巴毒素-β受体(TNF-RSF3)
编号:JN0447
英文名称:Recombinant Human Lymphotoxin beta Receptor
规格:10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Gln31-Met227在C端含有His标签。
TNFRSF3质量控制:>95%(还原性SDS-PAGE)
TNFRSF3制剂:冻干品
TNFRSF3保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
TNFRSF3复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于TNFRSF3:
Tumor necrosis factor receptor superfamily member 3, also known as Lymphotoxin-beta receptor,Tumor necrosis factor C receptor,Tumor necrosis factor receptor 2-related protein,Tumor necrosis factor receptor type III,LTBR,TNFCR, TNFR3 and TNFRSF3, is a member of the tumor necrosis factor (TNF) family of receptors. LTBR is a single-pass type I membrane protein and contains four TNFR-Cys repeats. It is expressed on the surface of most cell types, but not on T and B lymphocytes. LTBR and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of LTBR can trigger apoptosis. In addition, LTBR can lead to the release of the cytokine interleukin 8.
我公司生产供应销*(代"售")的重组蛋白正全品类优惠促销,十分期待您的咨询选购重组人肝细胞粘附分子(HEPACAM)现货价格。
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文献和实验一些受体的降解,在胆固醇和脂肪酸的代谢中起到重要作用。 Pcsk9能与肝细胞表面低密度脂蛋白受体 (low density lipoprotein receptor, LDLR) 结合, 构成复合物并靶向转运到溶酶体内进行降解, 从而阻断LDLR在细胞膜表面的循环途径, 抑制低密度脂蛋白胆固醇 (low density lipoproteincholesterol, LDL-C) 通过LDLR转运从体内清除代谢, 使得血浆中LDL-C升高, 最终导致动脉
数目增加;在肝细胞中,激活hM3Dq会增加血糖水平,也许是因为糖原分解和糖异生作用增加。 图3. hM3和乙酰胆碱结合,作为信号分子激活Gq耦联的GPCRs信号通路(2)Gi-DREADD和hM4Di: Y3.33和A5.46在不同的人毒蕈碱型乙酰胆碱受体亚型中是保守的,因此科学家同样可以突变M2和M4 mAchRs上的Y3.33、A5.46位点,由于M2、M4的下游激活的是Gi通道,于是产生Gi- DREADDs,命名为hM2Di和hM4Di,他们可以激活Gi调节的信号通路(图4)。Gi耦合
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