- $50 - 900
- prospecbio
- PRO-689
- 以色列
- 2025年07月15日
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- 详细信息
- 技术资料
- 库存：
大量
- 英文名：
Prelamin-A Recombinant
- 保质期：
1年
- 供应商：
上海沪震实业有限公司
- 保存条件：
-20°C
- 规格：
2μg/10μg/100μg
Prelamin-A
Prelamin-A is a structural component of the nuclear lamina and it is encoded by lamin A/C gene (LMNA). Due to the presence of a CAAX box sequence at carboxyl terminus, Prelamin-A in vivo goes through a serial of post-translational modifications, resulting in the farnesylation of the cysteine thiol, removal of the AAX tripeptide, carboxyl-methylation of the cysteinyl carboxy group and proteolysis of 18 C-terminal amino acids residues that lead to mature lamin A. Diverse mutations in the lamin A/C gene are associated with different deseases that are collectively called laminophaties, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. Recombinant human prelamin A is fused to a 6 Histidine tag at the N-terminus.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
CATALOGUE NUMBER
PRO-689
SYNONYMS
Prelamin-A/C, LMNA, LMN1, FPL, IDC, LFP, CDDC, EMD2, FPLD, HGPS, LDP1, LMNC, PRO1, CDCD1, CMD1A, FPLD2, LMNL1, CMT2B1, LGMD1B.DESCRIPTION
Recombinant Prelamin-A is a 74kDa precursor of the nuclear lamin A protein.Prelamin-A is a structural component of the nuclear lamina and it is encoded by lamin A/C gene (LMNA). Due to the presence of a CAAX box sequence at carboxyl terminus, Prelamin-A in vivo goes through a serial of post-translational modifications, resulting in the farnesylation of the cysteine thiol, removal of the AAX tripeptide, carboxyl-methylation of the cysteinyl carboxy group and proteolysis of 18 C-terminal amino acids residues that lead to mature lamin A. Diverse mutations in the lamin A/C gene are associated with different deseases that are collectively called laminophaties, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. Recombinant human prelamin A is fused to a 6 Histidine tag at the N-terminus.
SOURCE
Escherichia Coli.PHYSICAL APPEARANCE
Sterile filtered colorless solution.FORMULATION
The Prelamin-A solution (0.1mg/ml) contains 10% Glycerol.STABILITY
Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
AMINO ACID SEQUENCE
metpsqrrat rsgaqasstp lsptritrlq ekedlqelnd rlavyidrvr sletenaglr lriteseevv srevsgikaa yeaelgdark tldsvakera rlqlelskvr eefkelkarn tkkegdliaa qarlkdleal lnskeaalst alsekrtleg elhdlrgqva kleaalgeak kqlqdemlrr vdaenrlqtm keeldfqkni yseelretkr rhetrlveid ngkqrefesr ladalqelra qhedqveqyk kelektysak ldnarqsaer nsnlvgaahe elqqsririd slsaqlsqlq kqlaakeakl rdledslare rdtsrrllae keremaemra rmqqqldeyq elldiklald meihayrkll egeeerlrls psptsqrsrg rasshssqtq gggsvtkkrk lestesrssf sqhartsgrv aveevdeegk fvrlrnksne dqsmgnwqik rqngddpllt yrfppkftlk agqvvtiwaa gagathsppt dlvwkaqntw gcgnslrtal instgeevam rklvrsvtvv eddededgdd llhhhhgshc sssgdpaeyn lrsrtvlcgt cgqpadkasa sgsgaqvggp issgssassv tvtrsyrsvg gsgggsfgdn lvtrsyllgn ssprtqspqn csimPURITY
Greater than 90% as determined by SDS-PAGE.USAGE
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
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Prelamin-A
$50 - 900
