- $75 - 500
- prospecbio
- HIV-104
- 以色列
- 2025年07月07日
企业认证
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 库存：
大量
- 英文名：
Synthetic HIV-2 gp36
- 保质期：
1年
- 供应商：
上海沪震实业有限公司
- 保存条件：
-20°C
- 规格：
100µg/500µg/100µg
CATALOGUE NUMBER
HIV-104
INTRODUCTION
HIV-1 and HIV-2 appear to package their RNA differently. HIV-1 binds to any appropriate RNA whereas HIV-2 preferentially binds to mRNA which creates the Gag protein itself. This means that HIV-1 is better able to mutate. HIV-2 is transmitted in the same ways as HIV-1: Through exposure to bodily fluids such as blood, semen, tears and vaginal fluids. Immunodeficiency develops more slowly with HIV-2.HIV-2 is less infectious in the early stages of the virus than with HIV-1.
The infectiousness of HIV-2 increases as the virus progresses.
Major differences include reduced pathogenicity of HIV-2 relative to HIV-1, enhanced immune control of HIV-2 infection and often some degree of CD4-independence. Despite considerable sequence and phenotypic differences between HIV-1 and 2 envelopes, structurally they are quite similar. Both membrane-anchored proteins eventually form the 6-helix bundles from the N-terminal and C-terminal regions of the ectodomain, which is common to many viral and cellular fusion proteins and which seems to drive fusion.
HIV-1 gp41 helical regions can form more stable 6-helix bundles than HIV-2 gp41 helical regions however HIV-2 fusion occurs at a lower threshold temperature (25°C), does not require Ca2+ in the medium, is insensitive to treatment of target cells with cytochalasin B, and is not affected by target membrane glycosphingolipid composition.
DESCRIPTION
HIV-2 gp36 is full length chemically synthesized polypeptide sequence of HIV-2 envelope immunodominant regions.SOURCE
Synthetic.PHYSICAL APPEARANCE
Sterile filtered colorless clear solution.FORMULATION
(1mg/1ml) in H2O.PURITY
Greater than 95.0% as determined by HPLC.STABILITY
HIV-2 gp36 although stable at 4°C for 1 week, should be stored below -18°C.Please prevent freeze thaw cycles.
SPECIFICITY
Immunoreactive with all sera of HIV-2 infected individuals.APPLICATIONS
HIV-2 gp36 antigen is suitable for ELISA and Western blots, excellent antigen for early detection of HIV seroconvertors with minimal specificity problems.USAGE
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验liufengxi HIV-1 Tat (47-57) N-term Cys 序列 H-CYGRKKRRQRRR-NH2 ；原始HIV-1 Tat (47-57)序列为YGRKKRRQRRR 。N端的半胱氨酸修饰是为了利用其含有的巯基和其他分子反应，但是C端得-NH2的修饰是什么目的呢？有这个修饰的必要吗？是为了增强多肽的活性，还是发挥一个阻断活性COOH的作用？ 附件是关于HIV-1 Tat (47-57) N-term Cys的产品介绍。请高手
Lentivirus vectors are expected to become excellent tools for gene transfer in gene therapy and functional genomics and for engineering transgenic animals. When fully developed, their use will cover a whole gamut of endeavors, from discovery
The Fate of HIV-1 Capsid: A Biochemical Assay for HIV-1 Uncoating
The uncoating process of HIV-1 is a poorly understood process, so the development of a reliable assay to study uncoating is critical for moving the field forward. Here we describe an uncoating assay that currently represents the state
技术资料暂无技术资料 索取技术资料
