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- WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
- 详见说明书
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
蛋白酶体PSMα4/20S Proteasome α4抗体
- 抗体英文名：
Anti-PSMA4
- 靶点：
详见说明书
- 浓度：
1mg/1ml
- 应用范围：
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
- 宿主：
详见说明书
- 供应商：
上海一研
- 库存：
25
- 级别：
详见说明书
- 目录编号：
详见说明书
- 抗原来源：
Rabbit
- 保质期：
详见说明书
- 标记物：
详见说明书
- 克隆性：
多克隆
- 保存条件：
Store at -20 °C
- 形态：
详见说明书
- 亚型：
IgG
- 免疫原：
KLH conjugated synthetic peptide derived from Human PSMA4
- 规格：
0.2ml/200μg
蛋白酶体PSMα4/20S Proteasome α4抗体图片储存温度：
存在于血清、组织培养上清液或腹水中的抗体在-20℃下能够长期储存。低温存放不会损伤抗体活性。抗体的工作液通常储存于4℃中。此温度下，抗体的活性能稳定数月至数年亦不损失。抗体溶液不应反复冻融，因为反复冻融将导致部分抗体失活并产生不需要的蛋白—蛋白凝聚物。抗体的凝聚能导致活性丧失。这是由于抗原结合位点的空间构象被破坏，或由于产生的不溶物被离心或过滤而除去。冷凝蛋白类的抗体不能存放于4℃。因为在4℃下此类抗体会发生沉淀。一些鼠源性IgG3亚类的抗体有此特性。如果抗体在4℃下发生沉淀，就应该存放于室温下的叠氮钠溶液中。
蛋白酶体PSMα4/20S Proteasome α4抗体图片按理化性质和生物学功能，可将其分为IgM、IgG、IgA、IgE、IgD五类。
公司所有产品低价促销，更有惊喜等你拿，超值好产品，预定蛋白酶体PSMα4/20S Proteasome α4抗体图片即送好礼。好货提前订，快递更给力。产品质量好，到货快，质量三包。
英文名称 Anti-PSMA4
中文名称 蛋白酶体PSMα4/20S Proteasome α4抗体图片
别 名 HC9; HsT17706; Macropain subunit C9; MGC111191; MGC12467; MGC24813; Multicatalytic endopeptidase complex subunit C9; Proteasome (prosome macropain) subunit alpha type 4; Proteasome alpha 4 subunit; Proteasome component C9; Proteasome subunit alpha type 4; Proteasome subunit alpha type-4; Proteasome subunit HC9; Proteasome subunit L; PSA4_HUMAN; PSC9; PSMA 4; psmA4.
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Pig, Horse, Monkey
产品类型 一抗
研究领域 细胞生物 泛素
蛋白分子量 predicted molecular weight: 29kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from Human PSMA4
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 The proteasome represents a large protein complex that exists inside all eukaryotes and archaea, and in some bacteria. The main function of proteasomes is to degrade unnecessary or damaged proteins by proteolysis. The most common form of the proteasome, known as the 26S Proteasome, contains one 20S Proteasome core particle structure and two 19S regulatory caps. The 20S Proteasome core is hollow and forms an enclosed cavity, where proteins are degraded, as well as openings at the two ends to allow the target protein to enter. The 20S Proteasome core particle contains many subunits, depending on the organism. All of the subunits fall into one of two types: alpha subunits, which are structural, serve as docking domains for the regulatory particles and exterior gates blocking unregulated access to the interior cavity; or beta subunits, which are predominantly catalytic. The outer two rings in the proteasome consist of seven ?subunits each, and the inner two rings each consist of seven beta subunits.
Function : The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Location : Cytoplasm. Nucleus.
Similarity : Belongs to the peptidase T1A family.
Database links : UniProtKB/Swiss-Prot:
IgM抗体是免疫应答中首先分泌的抗体。它们在与抗原结合后启动补体的级联反应。它们还把入侵者相互连接起来，聚成一堆便于巨噬细胞的吞噬；
IgG抗体激活补体，中和多种毒素。IgG持续的时间长，是唯一能在母亲妊娠期穿过胎盘保护胎儿的抗体。他们还从乳腺分泌进入初乳，使新生儿得 到保护；
IgA抗体进入身体的黏 膜表面，包括呼吸、消化、生殖等管道的黏膜，中和感染因子。还可以通过母乳的初乳把这种抗体输送到新生儿的消化道黏膜中，是在母乳中含量最多，最为重要的一类抗体；
IgE抗体的尾部与嗜碱细胞、肥大细胞的细胞膜结合。当抗体与抗原结合后，嗜碱细胞与肥大细胞释放组织胺一类物质促进炎症的发展。这也是引发速发型过敏反应的抗体；
IgD抗体的作用还不太清楚。它们主要出现在成熟的B淋巴细胞表面上，可能与B细胞的分化有关。（IgD于1995年从人骨髓瘤蛋白中发现，分子量为175kD，主要由扁桃体、脾等处浆细胞产生，人血清中IgD浓度为3～40μg/ml,不到血清总Ig的1%，在个体发育中合成较晚。IgD铰链区很长，且对蛋白酶水解敏感，因此IgD半衰期很短，仅2.8天。血清中IgD确切的免疫功能尚不清楚。在B细胞分化到成熟B细胞阶段，除了表达SmIgD，抗原刺激后表现为免疫耐受。成熟B细胞活化后或者活化后或者变成记忆B细胞时，SmIgD逐渐消失。
蛋白酶体PSMα4/20S Proteasome α4抗体图片的分类：
按作用对象，可将其分为抗毒素、抗菌抗体、抗病毒抗体和亲细胞抗体（能与细胞结合的免疫球蛋白，如1型变态反应中的lgE反应素抗体，能吸附在靶细胞膜上）；按理化性质和生物学功能，可将其分为IgM、IgG、IgA、IgE、IgD五类；按抗体的来源，可 将其分为天然抗体和免疫抗体。抗体就是免疫球蛋白，是改变了的球蛋白分子。由特异性抗原刺激产生，抗体的产生是由于抗原侵入人体后引起各种免疫细胞相互作用，使淋巴细胞中的B细胞分化增殖而形成浆细胞，浆细胞可产生分泌抗体。
IL-13Ra2白细胞介素-13受体a2抗体规格:0.1ml
ABCA2三磷酸苷结合盒转运蛋白2抗体规格:0.2ml
FLIPdelta+gamma凋亡调节蛋白δ+γ抗体规格:0.2ml
SLC26A4钠碘单独转运蛋白SLC26A4抗体规格:0.1ml
HFREP1/FGL1肝细胞源性纤维蛋白原相关蛋白1抗体规格:0.2ml
FRS2成纤维细胞生因子受体底物2抗体规格:0.2ml
TBRG4转化生因子β调节蛋白4抗体规格:0.2ml
ABHD15水解酶结构域蛋白15抗体规格:0.2ml
APOL3载脂蛋白L3抗体规格:0.2ml
CCDC94卷曲螺旋结构域蛋白94抗体规格:0.2ml
HistoneH2A.x组蛋白H2AX抗体规格:0.2ml
LamininBeta1层粘连蛋白β1抗体规格:0.2mlIV-1 gag Protein p24 (137-154) Gly-Leu-Asn-Lys-Ile-Val-Arg-Met-Tyr-Ser-Pro-Thr-Ser-Ile-Leu-Asp-Ile-Arg
Influenza A NP (366-374) Strain A//NT//60//68 Ala-Ser-Asn-Glu-Asn-Met-Asp-Ala-Met
LEAP-2 (38-77) (Human) Met-Thr-Pro-Phe-Trp-Arg-Gly-Val-Ser-Leu-Arg-Pro-Ile-Gly-Ala-Ser-Cys-Arg-Asp-Asp-Ser-Glu-Cys-Ile-Thr-Arg-Leu-Cys-Arg-Lys-Arg-Arg-Cys-Ser-Leu-Ser-Val-Ala-Gln-Glu
MARCKS PSD-Derived Peptide, PKC Substrate Lys-Lys-Arg-Phe-Ser-Phe-Lys-Lys-Ser-Phe-Lys-Leu
Motilin, porcine Phe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Gln-Arg-Met-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly-Gln
Neuropeptide Y (porcine) Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2
蛋白酶体PSMα4/20S Proteasome α4抗体图片P55-TNFR Leu-Pro-Gln-Ile-Glu-Asn-Val-Lys-Gly-Thr-Glu-Asp
PDGF b-Receptor (719-723) (phosphorylated) PDGF b-Receptor (719-723) (phosphorylated)
Prepro-Atrial Natriuretic Factor (104-123) (human) Ser-Ser-Asp-Arg-Ser-Ala-Leu-Leu-Lys-Ser-Lys-Leu-Arg-Ala-Leu-Leu-Thr-Ala-Pro-Arg
RC-160(Vapreotide) D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2
SEQ ID NO:549 Phe-Leu-Gly-Lys-Ile-Trp-Pro-Ser-Tyr-Lys
Substance P reversed sequence Met-Leu-Gly-Phe-Phe-Gln-Gln-Pro-Lys-Pro-Arg-NH2
Tyrosine Kinase Peptide 3 [RRLIEDAE-pY-AARG], Acetylated, Amide, Phosphorylated Ac-Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-pTyr-Ala-Ala-Arg-Gly-NH2
存在于血清、组织培养上清液或腹水中的抗体在-20℃下能够长期储存。低温存放不会损伤抗体活性。抗体的工作液通常储存于4℃中。此温度下，抗体的活性能稳定数月至数年亦不损失。抗体溶液不应反复冻融，因为反复冻融将导致部分抗体失活并产生不需要的蛋白—蛋白凝聚物。抗体的凝聚能导致活性丧失。这是由于抗原结合位点的空间构象被破坏，或由于产生的不溶物被离心或过滤而除去。冷凝蛋白类的抗体不能存放于4℃。因为在4℃下此类抗体会发生沉淀。一些鼠源性IgG3亚类的抗体有此特性。如果抗体在4℃下发生沉淀，就应该存放于室温下的叠氮钠溶液中。
蛋白酶体PSMα4/20S Proteasome α4抗体图片按理化性质和生物学功能，可将其分为IgM、IgG、IgA、IgE、IgD五类。
公司所有产品低价促销，更有惊喜等你拿，超值好产品，预定蛋白酶体PSMα4/20S Proteasome α4抗体图片即送好礼。好货提前订，快递更给力。产品质量好，到货快，质量三包。
英文名称 Anti-PSMA4
中文名称 蛋白酶体PSMα4/20S Proteasome α4抗体图片
别 名 HC9; HsT17706; Macropain subunit C9; MGC111191; MGC12467; MGC24813; Multicatalytic endopeptidase complex subunit C9; Proteasome (prosome macropain) subunit alpha type 4; Proteasome alpha 4 subunit; Proteasome component C9; Proteasome subunit alpha type 4; Proteasome subunit alpha type-4; Proteasome subunit HC9; Proteasome subunit L; PSA4_HUMAN; PSC9; PSMA 4; psmA4.
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Pig, Horse, Monkey
产品类型 一抗
研究领域 细胞生物 泛素
蛋白分子量 predicted molecular weight: 29kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from Human PSMA4
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 The proteasome represents a large protein complex that exists inside all eukaryotes and archaea, and in some bacteria. The main function of proteasomes is to degrade unnecessary or damaged proteins by proteolysis. The most common form of the proteasome, known as the 26S Proteasome, contains one 20S Proteasome core particle structure and two 19S regulatory caps. The 20S Proteasome core is hollow and forms an enclosed cavity, where proteins are degraded, as well as openings at the two ends to allow the target protein to enter. The 20S Proteasome core particle contains many subunits, depending on the organism. All of the subunits fall into one of two types: alpha subunits, which are structural, serve as docking domains for the regulatory particles and exterior gates blocking unregulated access to the interior cavity; or beta subunits, which are predominantly catalytic. The outer two rings in the proteasome consist of seven ?subunits each, and the inner two rings each consist of seven beta subunits.
Function : The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
Subcellular Location : Cytoplasm. Nucleus.
Similarity : Belongs to the peptidase T1A family.
Database links : UniProtKB/Swiss-Prot:
IgM抗体是免疫应答中首先分泌的抗体。它们在与抗原结合后启动补体的级联反应。它们还把入侵者相互连接起来，聚成一堆便于巨噬细胞的吞噬；
IgG抗体激活补体，中和多种毒素。IgG持续的时间长，是唯一能在母亲妊娠期穿过胎盘保护胎儿的抗体。他们还从乳腺分泌进入初乳，使新生儿得 到保护；
IgA抗体进入身体的黏 膜表面，包括呼吸、消化、生殖等管道的黏膜，中和感染因子。还可以通过母乳的初乳把这种抗体输送到新生儿的消化道黏膜中，是在母乳中含量最多，最为重要的一类抗体；
IgE抗体的尾部与嗜碱细胞、肥大细胞的细胞膜结合。当抗体与抗原结合后，嗜碱细胞与肥大细胞释放组织胺一类物质促进炎症的发展。这也是引发速发型过敏反应的抗体；
IgD抗体的作用还不太清楚。它们主要出现在成熟的B淋巴细胞表面上，可能与B细胞的分化有关。（IgD于1995年从人骨髓瘤蛋白中发现，分子量为175kD，主要由扁桃体、脾等处浆细胞产生，人血清中IgD浓度为3～40μg/ml,不到血清总Ig的1%，在个体发育中合成较晚。IgD铰链区很长，且对蛋白酶水解敏感，因此IgD半衰期很短，仅2.8天。血清中IgD确切的免疫功能尚不清楚。在B细胞分化到成熟B细胞阶段，除了表达SmIgD，抗原刺激后表现为免疫耐受。成熟B细胞活化后或者活化后或者变成记忆B细胞时，SmIgD逐渐消失。
蛋白酶体PSMα4/20S Proteasome α4抗体图片的分类：
按作用对象，可将其分为抗毒素、抗菌抗体、抗病毒抗体和亲细胞抗体（能与细胞结合的免疫球蛋白，如1型变态反应中的lgE反应素抗体，能吸附在靶细胞膜上）；按理化性质和生物学功能，可将其分为IgM、IgG、IgA、IgE、IgD五类；按抗体的来源，可 将其分为天然抗体和免疫抗体。抗体就是免疫球蛋白，是改变了的球蛋白分子。由特异性抗原刺激产生，抗体的产生是由于抗原侵入人体后引起各种免疫细胞相互作用，使淋巴细胞中的B细胞分化增殖而形成浆细胞，浆细胞可产生分泌抗体。
IL-13Ra2白细胞介素-13受体a2抗体规格:0.1ml
ABCA2三磷酸苷结合盒转运蛋白2抗体规格:0.2ml
FLIPdelta+gamma凋亡调节蛋白δ+γ抗体规格:0.2ml
SLC26A4钠碘单独转运蛋白SLC26A4抗体规格:0.1ml
HFREP1/FGL1肝细胞源性纤维蛋白原相关蛋白1抗体规格:0.2ml
FRS2成纤维细胞生因子受体底物2抗体规格:0.2ml
TBRG4转化生因子β调节蛋白4抗体规格:0.2ml
ABHD15水解酶结构域蛋白15抗体规格:0.2ml
APOL3载脂蛋白L3抗体规格:0.2ml
CCDC94卷曲螺旋结构域蛋白94抗体规格:0.2ml
HistoneH2A.x组蛋白H2AX抗体规格:0.2ml
LamininBeta1层粘连蛋白β1抗体规格:0.2mlIV-1 gag Protein p24 (137-154) Gly-Leu-Asn-Lys-Ile-Val-Arg-Met-Tyr-Ser-Pro-Thr-Ser-Ile-Leu-Asp-Ile-Arg
Influenza A NP (366-374) Strain A//NT//60//68 Ala-Ser-Asn-Glu-Asn-Met-Asp-Ala-Met
LEAP-2 (38-77) (Human) Met-Thr-Pro-Phe-Trp-Arg-Gly-Val-Ser-Leu-Arg-Pro-Ile-Gly-Ala-Ser-Cys-Arg-Asp-Asp-Ser-Glu-Cys-Ile-Thr-Arg-Leu-Cys-Arg-Lys-Arg-Arg-Cys-Ser-Leu-Ser-Val-Ala-Gln-Glu
MARCKS PSD-Derived Peptide, PKC Substrate Lys-Lys-Arg-Phe-Ser-Phe-Lys-Lys-Ser-Phe-Lys-Leu
Motilin, porcine Phe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Gln-Arg-Met-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly-Gln
Neuropeptide Y (porcine) Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2
蛋白酶体PSMα4/20S Proteasome α4抗体图片P55-TNFR Leu-Pro-Gln-Ile-Glu-Asn-Val-Lys-Gly-Thr-Glu-Asp
PDGF b-Receptor (719-723) (phosphorylated) PDGF b-Receptor (719-723) (phosphorylated)
Prepro-Atrial Natriuretic Factor (104-123) (human) Ser-Ser-Asp-Arg-Ser-Ala-Leu-Leu-Lys-Ser-Lys-Leu-Arg-Ala-Leu-Leu-Thr-Ala-Pro-Arg
RC-160(Vapreotide) D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2
SEQ ID NO:549 Phe-Leu-Gly-Lys-Ile-Trp-Pro-Ser-Tyr-Lys
Substance P reversed sequence Met-Leu-Gly-Phe-Phe-Gln-Gln-Pro-Lys-Pro-Arg-NH2
Tyrosine Kinase Peptide 3 [RRLIEDAE-pY-AARG], Acetylated, Amide, Phosphorylated Ac-Arg-Arg-Leu-Ile-Glu-Asp-Ala-Glu-pTyr-Ala-Ala-Arg-Gly-NH2
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Studies of the Ubiquitin Proteasome System
or other proteasome inhibitor (e.g., lactacystin; Calbiochem or Biomol) Phosphate‐buffered saline (PBS; see recipe ) Nondenaturing Triton X‐100 lysis buffer (see recipe ) containing 1×
, members of a new family of threonine (Thr)-proteases. The outer rings, made of α-subunits, bind the regulators that control the substrate specificity of the proteasome. The binding of a 19S regulator to each end of the 20S core creates the 26S proteasome
each of seven different α and β subunits arranged into four stacked rings (α7 β7 β7 α7 ). Separation by two-dimensional (2D) gel electrophoresis of the human erythrocytes 20S proteasome subunits and mass spectrometry (MS) identification of all the observed spots reveal
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蛋白酶体PSMα4/20S Proteasome α4抗体图片
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