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- 2025年12月17日
- WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 I
- 详见说明书
- 详见说明书
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- 技术资料
- 抗体名：
磷酸化视网膜母细胞瘤相关蛋白1抗体
- 抗体英文名：
Anti-Phospho-Rb/P105 RB (Ser788)
- 靶点：
详见说明书
- 浓度：
1mg/1ml
- 应用范围：
WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 I
- 宿主：
详见说明书
- 供应商：
上海一研
- 库存：
45
- 级别：
详见说明书
- 目录编号：
详见说明书
- 抗原来源：
Rabbit
- 保质期：
详见说明书
- 适应物种：
详见说明书
- 标记物：
详见说明书
- 克隆性：
多克隆
- 保存条件：
Store at -20 °C
- 形态：
详见说明书
- 亚型：
IgG
- 免疫原：
Lyophilized or Liquid 免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Retinoblastoma associated protein around the phosphorylation site of Ser788
- 规格：
0.1ml/100μg
公司抗体应用于WB、IHC、IF、ELISA等实验中，磷酸化视网膜母细胞瘤相关蛋白1抗体品牌品质保证，提供完善的售前、售中、售后服务！欢迎来电咨询或联系在线客服！我们将竭诚为您服务！
英文名称 Anti-Phospho-Rb/P105 RB (Ser788)
中文名称 磷酸化视网膜母细胞瘤相关蛋白1抗体品牌
别 名 RB1(phospho S788); OSRC; P105 RB; P105RB; PP105; PP110; pRb; RB 1; RB1; RB1 protein; Retinoblastoma 1 (including osteosarcoma); Retinoblastoma 1; Retinoblastoma associated protein; Retinoblastoma related osteosarcoma; Retinoblastoma susceptibility gene; Including osteosarcoma; RB_HUMAN.
浓 度 1mg/1ml
规 格 0.1ml/100μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep
产品类型 一抗 磷酸化抗体
研究领域 肿瘤 免疫学 信号转导 转录调节因子
蛋白分子量 predicted molecular weight: 102kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Retinoblastoma associated protein around the phosphorylation site of Ser788
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F1, PU1, ATF2, UBF, Elf1 and cAbl. This ability of Rb to alter transcription is regulated by phosphorylation catalyzed by the cyclin dependent protein kinases (cdks). Rb is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus 16E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
Function : Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.
Subunit : Interacts with ATAD5. Interacts with PRMT2, CDK1 and CDK2. The hypophosphorylated form interacts with and sequesters the E2F1 transcription factor. Interacts with heterodimeric E2F/DP transcription factor complexes containing TFDP1 and either E2F1, E2F3, E2F4 or E2F5, or TFDP2 and E2F4. The unphosphorylated form interacts with EID1, ARID3B, KDM5A, SUV39H1, MJD2A/JHDM3A and THOC1. Interacts with the N-terminal domain of TAF1. Interacts with AATF, DNMT1, LIN9, LMNA, SUV420H1, SUV420H2, PELP1 and TMPO-alpha. May interact with NDC80. Interacts with GRIP1 and UBR4. Interacts with ARID4A and KDM5B. Interacts with E4F1 and LIMD1. Interacts with SMARCA4/BRG1 AND HDAC1. Interacts with adenovirus E1A protein, HPV E7 protein and SV40 large T antigen. Interacts with PSMA3 and USP4. Interacts (when methylated at Lys-860) with L3MBTL1.
Subcellular Location : Nucleus.
Tissue Specificity : Expressed in the retina.
Post-translational modifications : Phosphorylated by CDK6 and CDK4, and subsequently by CDK2 at Ser-567 in G1, thereby releasing E2F1 which is then able to activate cell growth. Dephosphorylated at the late M phase. SV40 large T antigen, HPV E7 and adenovirus E1A bind to the underphosphorylated, active form of pRb. Phosphorylation at Thr-821 and Thr-826 promotes interaction between the C-terminal domain C and the Pocket domain, and thereby inhibits interactions with heterodimeric E2F/DP transcription factor complexes. Dephosphorylated at Ser-795 by calcineruin upon calcium stimulation. CDK3/cyclin-C-mediated phosphorylation at Ser-807 and Ser-811 is required for G0-G1 transition. Phosphorylated by CDK1 and CDK2 upon TGFB1-mediated apoptosis.
N-terminus is methylated by METTL11A/NTM1. Monomethylated at Lys-860 by SMYD2, promoting interaction with L3MBTL1.
DISEASE : Defects in RB1 are the cause of childhood cancer retinoblastoma (RB) [MIM:180200]. RB is a congenital malignant tumor that arises from the nuclear layers of the retina. It occurs in about 1:20'000 live births and represents about 2% of childhood malignancies. It is bilateral in about 30% of cases. Although most RB appear sporadically, about 20% are transmitted as an autosomal dominant trait with incomplete penetrance. The diagnosis is usually made before the age of 2 years when strabismus or a gray to yellow reflex from pupil ('cat eye') is investigated.
Defects in RB1 are a cause of susceptibility to bladder cancer (BLC) [MIM:109800]. A malignancy originating in tissues of the urinary bladder. It often presents with multiple tumors appearing at different times and at different sites in the bladder. Most bladder cancers are transitional cell carcinomas. They begin in cells that normally make up the inner lining of the bladder. Other types of bladder cancer include squamous cell carcinoma (cancer that begins in thin, flat cells) and adenocarcinoma (cancer that begins in cells that make and release mucus and other fluids). Bladder cancer is a complex disorder with both genetic and environmental influences.
Defects in RB1 are a cause of osteogenic sarcoma (OSRC) [MIM:259500].
Similarity : Belongs to the retinoblastoma protein (RB) family.
Database links : UniProtKB/Swiss-Prot: P06400.2
磷酸化视网膜母细胞瘤相关蛋白1抗体品牌具有高度的特异性，免疫组织化学正是利用了这一原理。先将组织或细胞中的某种化学物质提取出来，以此作为抗原或半抗原，通过免疫动物后获得特异性的抗体，再以此抗体去探测组织或细胞中的同类的抗原物质。由于抗原与抗体的复合物是无色的，因此还必须借助于组织化学的方法将抗原抗体结合的部位显示出来，以其达到对组织或细胞中的未知抗原进行定性，定位或定量的研究。
磷酸化视网膜母细胞瘤相关蛋白1抗体品牌包括以下几个步骤：
1、制备抗原。
2、选择实验动物。
3、动物免疫。
4、试取血进行测试，看看是否成功免疫。
5、如果成功免疫，杀死实验动物，采集全部血清。
6、纯化出抗体。
7、鉴定抗体。包括纯度以及特异性。
磷酸化视网膜母细胞瘤相关蛋白1抗体品牌的功能
抗体的主要功能是与抗原（包括外来的和自身的）相结合，从而有效地清除侵入机体内的微生物、寄生虫等异物，抗体（antibody）是一种应答抗原产生的、可与抗原特异性结合的蛋白质。每种抗体与特定的抗原决定基结合。这种结合可以使抗原失活，也可能无效但有时也会对机体造成病理性损害，如抗核抗体、抗双链DNA抗体、抗甲状腺球蛋白抗体等一些自身抗体的产生，对人体可造成危害。
磷酸化视网膜母细胞瘤相关蛋白1抗体品牌的优点：
①耐热、耐酸、耐碱、抗有机溶剂以及金属离子，稳定性好，室温下可以长期保存；
②制备简单，操作方便，可以进行批量；
③不必免疫动物，且可获得免疫动物所不能得到的“抗体”；
④可以反复使用；
⑤价格低廉。因此，设计、合成既具有类似生物抗体的高亲合性和高专一性，又具有耐热、耐酸、耐碱且又可以长期稳定的人工抗体，在部分领域替代生物抗体以进行仿生分子识别，或者完成一些生物抗体所不能完成的工作，具有重要的科学意义，在化学、生命科学和环境科学等方面具有广阔的应用前景
公司专业供应各种进口、国产一抗及二抗，品牌有R&D、Santa Cruz、Bipec、Millipore等国际知名品牌，品种多达7000多种，由于产品的数量众多，产品的宿主、抗原来源及应用范围(WB、IH(F/P)、FC、ELISA、IP、IF等)有所不同。
MMB018 （10 mg） methyl （1-pentyl-1H-indole-3-carbonyl）-L-valinate
Guanosine 5′-triphosphate （sodium salt hydrate） （10 mg） GTP；
TIQ-A （10 mg） thieno[2,
Seco Rapamycin （sodium salt） （5 mg） [2R-
ABT-199 （10 mg） GDC 0199； 4-
Tenovin-3 （5 mg） N-
Ponasterone A （10 mg） 25-Deoxyecdysterone； （5β）-2β,3β,14,20,22R-pentahydroxy-cholest-7-en-6-one
Danazol （50 mg） Danocrine|Ladogal|NSC 270916|WIN 17,757； pregna-2,4-dien-20-yno[2,3-d]isoxazol-17α-ol
NT 烟酰胺核苷酸转酶抗体规格: 0.2mlHECA HECA蛋白抗体规格: 0.2ml
RANK/CD265 核转录因子NF-κB受体抗体(核因子kB受体活化因子)规格: 0.1mlRabbit Anti-mouse IgG-Fc/RBITC 罗丹明标记的兔抗小鼠IgG-Fc规格: 0.1ml
磷酸化视网膜母细胞瘤相关蛋白1抗体品牌phospho-CDKN2A/P16 (Ser140) 磷酸化抑基因p16抗体规格: 0.1mlphospho-APP/ABPP (Ser730) 磷酸化APP淀粉样肽前体蛋白抗体规格: 0.1ml
CNKSR1 Ras激酶抑制因子连接增强蛋白1抗体规格: 0.2mlCystatin A 胱抑素A/半胱氨酸蛋白酶抑制剂A抗体规格: 0.2ml
beta-Amyloid(1-28) β淀粉样肽（1-28）抗体规格: 0.1mlPhospho-IKK alpha/IKK beta (Ser180/Ser181) 磷酸化KB抑制蛋白激酶α/β抗体规格: 0.1ml
HDDC3 四磷酸鸟苷水解酶抗体规格: 0.2mlMSX1 MSH同源蛋白1样蛋白抗体规格: 0.2ml
COX5A 细胞色素c氧化酶5A抗体规格: 0.2mlSDHC 琥珀酸细胞色素亚基B560抗体规格: 0.2ml
CXCL15/Lungkine 趋化因子CXCL15抗体规格: 0.2mlNAIF1 protein 核凋亡诱导因子蛋白1规格: 0.2ml
Mesothelioma 间质细胞蛋白抗体规格: 0.2mlSAMD15/C14orf174 14号染色体开放阅读框174规格: 0.2ml
phospho-MAP4(Ser941) 磷酸化微管相关蛋白4抗体规格: 0.1mlRabbit Anti-dog IgG/PE-CY5 PE-CY5标记的兔抗狗IgG规格: 0.1ml
Microsporidia protien 蜜蜂微孢子虫蛋白抗体规格: 1mlWASF2 WASF2抗体规格: 0.2ml
MIP4/CCL18 巨噬细胞炎症蛋白18抗体规格: 0.1mlDNase gamma 脱氧核糖核酸酶γ抗体规格: 0.2ml
英文名称 Anti-Phospho-Rb/P105 RB (Ser788)
中文名称 磷酸化视网膜母细胞瘤相关蛋白1抗体品牌
别 名 RB1(phospho S788); OSRC; P105 RB; P105RB; PP105; PP110; pRb; RB 1; RB1; RB1 protein; Retinoblastoma 1 (including osteosarcoma); Retinoblastoma 1; Retinoblastoma associated protein; Retinoblastoma related osteosarcoma; Retinoblastoma susceptibility gene; Including osteosarcoma; RB_HUMAN.
浓 度 1mg/1ml
规 格 0.1ml/100μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep
产品类型 一抗 磷酸化抗体
研究领域 肿瘤 免疫学 信号转导 转录调节因子
蛋白分子量 predicted molecular weight: 102kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Retinoblastoma associated protein around the phosphorylation site of Ser788
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F1, PU1, ATF2, UBF, Elf1 and cAbl. This ability of Rb to alter transcription is regulated by phosphorylation catalyzed by the cyclin dependent protein kinases (cdks). Rb is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus 16E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
Function : Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.
Subunit : Interacts with ATAD5. Interacts with PRMT2, CDK1 and CDK2. The hypophosphorylated form interacts with and sequesters the E2F1 transcription factor. Interacts with heterodimeric E2F/DP transcription factor complexes containing TFDP1 and either E2F1, E2F3, E2F4 or E2F5, or TFDP2 and E2F4. The unphosphorylated form interacts with EID1, ARID3B, KDM5A, SUV39H1, MJD2A/JHDM3A and THOC1. Interacts with the N-terminal domain of TAF1. Interacts with AATF, DNMT1, LIN9, LMNA, SUV420H1, SUV420H2, PELP1 and TMPO-alpha. May interact with NDC80. Interacts with GRIP1 and UBR4. Interacts with ARID4A and KDM5B. Interacts with E4F1 and LIMD1. Interacts with SMARCA4/BRG1 AND HDAC1. Interacts with adenovirus E1A protein, HPV E7 protein and SV40 large T antigen. Interacts with PSMA3 and USP4. Interacts (when methylated at Lys-860) with L3MBTL1.
Subcellular Location : Nucleus.
Tissue Specificity : Expressed in the retina.
Post-translational modifications : Phosphorylated by CDK6 and CDK4, and subsequently by CDK2 at Ser-567 in G1, thereby releasing E2F1 which is then able to activate cell growth. Dephosphorylated at the late M phase. SV40 large T antigen, HPV E7 and adenovirus E1A bind to the underphosphorylated, active form of pRb. Phosphorylation at Thr-821 and Thr-826 promotes interaction between the C-terminal domain C and the Pocket domain, and thereby inhibits interactions with heterodimeric E2F/DP transcription factor complexes. Dephosphorylated at Ser-795 by calcineruin upon calcium stimulation. CDK3/cyclin-C-mediated phosphorylation at Ser-807 and Ser-811 is required for G0-G1 transition. Phosphorylated by CDK1 and CDK2 upon TGFB1-mediated apoptosis.
N-terminus is methylated by METTL11A/NTM1. Monomethylated at Lys-860 by SMYD2, promoting interaction with L3MBTL1.
DISEASE : Defects in RB1 are the cause of childhood cancer retinoblastoma (RB) [MIM:180200]. RB is a congenital malignant tumor that arises from the nuclear layers of the retina. It occurs in about 1:20'000 live births and represents about 2% of childhood malignancies. It is bilateral in about 30% of cases. Although most RB appear sporadically, about 20% are transmitted as an autosomal dominant trait with incomplete penetrance. The diagnosis is usually made before the age of 2 years when strabismus or a gray to yellow reflex from pupil ('cat eye') is investigated.
Defects in RB1 are a cause of susceptibility to bladder cancer (BLC) [MIM:109800]. A malignancy originating in tissues of the urinary bladder. It often presents with multiple tumors appearing at different times and at different sites in the bladder. Most bladder cancers are transitional cell carcinomas. They begin in cells that normally make up the inner lining of the bladder. Other types of bladder cancer include squamous cell carcinoma (cancer that begins in thin, flat cells) and adenocarcinoma (cancer that begins in cells that make and release mucus and other fluids). Bladder cancer is a complex disorder with both genetic and environmental influences.
Defects in RB1 are a cause of osteogenic sarcoma (OSRC) [MIM:259500].
Similarity : Belongs to the retinoblastoma protein (RB) family.
Database links : UniProtKB/Swiss-Prot: P06400.2
磷酸化视网膜母细胞瘤相关蛋白1抗体品牌具有高度的特异性，免疫组织化学正是利用了这一原理。先将组织或细胞中的某种化学物质提取出来，以此作为抗原或半抗原，通过免疫动物后获得特异性的抗体，再以此抗体去探测组织或细胞中的同类的抗原物质。由于抗原与抗体的复合物是无色的，因此还必须借助于组织化学的方法将抗原抗体结合的部位显示出来，以其达到对组织或细胞中的未知抗原进行定性，定位或定量的研究。
磷酸化视网膜母细胞瘤相关蛋白1抗体品牌包括以下几个步骤：
1、制备抗原。
2、选择实验动物。
3、动物免疫。
4、试取血进行测试，看看是否成功免疫。
5、如果成功免疫，杀死实验动物，采集全部血清。
6、纯化出抗体。
7、鉴定抗体。包括纯度以及特异性。
磷酸化视网膜母细胞瘤相关蛋白1抗体品牌的功能
抗体的主要功能是与抗原（包括外来的和自身的）相结合，从而有效地清除侵入机体内的微生物、寄生虫等异物，抗体（antibody）是一种应答抗原产生的、可与抗原特异性结合的蛋白质。每种抗体与特定的抗原决定基结合。这种结合可以使抗原失活，也可能无效但有时也会对机体造成病理性损害，如抗核抗体、抗双链DNA抗体、抗甲状腺球蛋白抗体等一些自身抗体的产生，对人体可造成危害。
磷酸化视网膜母细胞瘤相关蛋白1抗体品牌的优点：
①耐热、耐酸、耐碱、抗有机溶剂以及金属离子，稳定性好，室温下可以长期保存；
②制备简单，操作方便，可以进行批量；
③不必免疫动物，且可获得免疫动物所不能得到的“抗体”；
④可以反复使用；
⑤价格低廉。因此，设计、合成既具有类似生物抗体的高亲合性和高专一性，又具有耐热、耐酸、耐碱且又可以长期稳定的人工抗体，在部分领域替代生物抗体以进行仿生分子识别，或者完成一些生物抗体所不能完成的工作，具有重要的科学意义，在化学、生命科学和环境科学等方面具有广阔的应用前景
公司专业供应各种进口、国产一抗及二抗，品牌有R&D、Santa Cruz、Bipec、Millipore等国际知名品牌，品种多达7000多种，由于产品的数量众多，产品的宿主、抗原来源及应用范围(WB、IH(F/P)、FC、ELISA、IP、IF等)有所不同。
MMB018 （10 mg） methyl （1-pentyl-1H-indole-3-carbonyl）-L-valinate
Guanosine 5′-triphosphate （sodium salt hydrate） （10 mg） GTP；
TIQ-A （10 mg） thieno[2,
Seco Rapamycin （sodium salt） （5 mg） [2R-
ABT-199 （10 mg） GDC 0199； 4-
Tenovin-3 （5 mg） N-
Ponasterone A （10 mg） 25-Deoxyecdysterone； （5β）-2β,3β,14,20,22R-pentahydroxy-cholest-7-en-6-one
Danazol （50 mg） Danocrine|Ladogal|NSC 270916|WIN 17,757； pregna-2,4-dien-20-yno[2,3-d]isoxazol-17α-ol
NT 烟酰胺核苷酸转酶抗体规格: 0.2mlHECA HECA蛋白抗体规格: 0.2ml
RANK/CD265 核转录因子NF-κB受体抗体(核因子kB受体活化因子)规格: 0.1mlRabbit Anti-mouse IgG-Fc/RBITC 罗丹明标记的兔抗小鼠IgG-Fc规格: 0.1ml
磷酸化视网膜母细胞瘤相关蛋白1抗体品牌phospho-CDKN2A/P16 (Ser140) 磷酸化抑基因p16抗体规格: 0.1mlphospho-APP/ABPP (Ser730) 磷酸化APP淀粉样肽前体蛋白抗体规格: 0.1ml
CNKSR1 Ras激酶抑制因子连接增强蛋白1抗体规格: 0.2mlCystatin A 胱抑素A/半胱氨酸蛋白酶抑制剂A抗体规格: 0.2ml
beta-Amyloid(1-28) β淀粉样肽（1-28）抗体规格: 0.1mlPhospho-IKK alpha/IKK beta (Ser180/Ser181) 磷酸化KB抑制蛋白激酶α/β抗体规格: 0.1ml
HDDC3 四磷酸鸟苷水解酶抗体规格: 0.2mlMSX1 MSH同源蛋白1样蛋白抗体规格: 0.2ml
COX5A 细胞色素c氧化酶5A抗体规格: 0.2mlSDHC 琥珀酸细胞色素亚基B560抗体规格: 0.2ml
CXCL15/Lungkine 趋化因子CXCL15抗体规格: 0.2mlNAIF1 protein 核凋亡诱导因子蛋白1规格: 0.2ml
Mesothelioma 间质细胞蛋白抗体规格: 0.2mlSAMD15/C14orf174 14号染色体开放阅读框174规格: 0.2ml
phospho-MAP4(Ser941) 磷酸化微管相关蛋白4抗体规格: 0.1mlRabbit Anti-dog IgG/PE-CY5 PE-CY5标记的兔抗狗IgG规格: 0.1ml
Microsporidia protien 蜜蜂微孢子虫蛋白抗体规格: 1mlWASF2 WASF2抗体规格: 0.2ml
MIP4/CCL18 巨噬细胞炎症蛋白18抗体规格: 0.1mlDNase gamma 脱氧核糖核酸酶γ抗体规格: 0.2ml
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文献和实验相关实验
keep-smile 最近在做原代培养的神经细胞的凋亡研究。对于六孔板中蛋白提取有些疑问。药物处理后，总有一些细胞漂浮起来，估计就是凋亡或坏死细胞，直接吸弃培养基怕对凋亡相关蛋白检测有影响。如果细胞消化离心，又担心提取不够迅速使一些目的蛋白去磷酸化，比如MAPK信号通路蛋白。请问大家，应该怎么解决这个问题呢，有什么好的办法？ ronaldo_zj 1. 我们也遇到过类似问题，但经过检测，我们发现培养基上清漂浮的细胞确实就是晚期
【求助】如何证明GSK-3beta的抑制是由Wnt通路引起的？
magichunter 我现在能够证明GSK-3beta的活性受到了抑制，同时也证明了b-catenin在核内和胞浆内的表达都升高了，同时胞浆内的磷酸化b-catenin含量降低（Wnt通路被激活了吗）。另外Akt的磷酸化增高（应该是PI3K/Akt通路被激活了）。因为Wnt和PI3K/Akt两条通路都可以抑制GSK的活性。 请问能否判断GSK的抑制是由Wnt通路的激活引起的，还是有PI3K/Akt的激活引起的？还是两条通路都激活了？ （暂时我还不能进行
表观遗传是指 DNA 序列不发生变化但基因表达却发生了可遗传的改变，即基因型未发生变化而表型却发生了改变。换言之，这是一种 DNA 序列外的遗传方式。因素如 DNA 甲基化、组蛋白修饰和 miRNA 是对环境刺激因素变化的反映，这些表观遗传学因素相互作用以调节基因表达，控制细胞表型，所有这些表观遗传学因素都是维持机体内环境稳定所必需的，有助于正常生理功能的发挥。 组蛋白的翻译后修饰不仅与染色体的重塑和功能紧密相关，而且在决定细胞命运、细胞生长以及致癌作用的过程中发挥着重要的作用，如组蛋白磷酸化
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磷酸化视网膜母细胞瘤相关蛋白1抗体品牌
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