FBXO4 Antibody (Center) | LBP6

商品分类：多克隆抗体

产品概述：FBXO4 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein belongs to the Fbxs class.

靶点/蛋白：This FBXO4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 225-251 amino acids from the Central region of human FBXO4.

来源：Rabbit

存储溶液：Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

参考文献：Zeng,Z., et.al., Dev. Cell 18 (2), 214-225 (2010) Barbash,O., et.al., Cancer Cell 14 (1), 68-78 (2008) Sugiyama,N., et.al., Mol. Cell Proteomics 6 (6), 1103-1109 (2007)

特异性：Human

别名：F-box only protein 4, FBXO4, FBX4

应用：WB~~1:1000

简单描述：Rabbit Polyclonal FBXO4 Antibody (Center). Validated for use in WB, E.

详情：Function Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1. Cellular_Location Cytoplasm.