重组人Txndc4(Erp44) 分子生物学试剂

特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、医疗及其他非科研用途。

北京百奥莱博主要从事生物试剂的生产和销*(代"售")，产品线涵盖重组人Txndc4(Erp44) 分子生物学试剂在内的分子生物学试剂产品，还包括PCR及荧光定量PCR、核酸提取试剂盒类、样本核酸保护试剂、核酸提取、克隆与转化、蛋白纯化、蛋白检测、免疫组化、细胞凋亡与抗体等。

名称：重组人Txndc4(Erp44) 分子生物学试剂
规格：10μg|50μg|500μg|1mg
编号：JN1145
产地：国产|进口
品牌：百奥莱博
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Glu30-Asp402在C端含有His标签。

TXNDC4质量控制：＞95%(还原性SDS-PAGE)

TXNDC4制剂：液体

TXNDC4保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于TXNDC4：
Endoplasmic reticulum resident protein 44 (TXNDC4) is is a 406 amino acid protein that contains one thioredoxin domain. TXNDC4 mediates thiol-dependent retention in the early secretory pathway and forms mixed disulfides with substrate proteins through its conserved CRFS motif.It can inhibit the calcium channel activity of ITPR1.It may have a role in the control of oxidative protein folding in the endoplasmic reticulum.

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·重组人骨硬化蛋白(Sclerostin)(SOST)
编号：JN1141
英文名称：Recombinant Human Sclerostin
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Gln24-Tyr213在C端含有His标签。

SOST质量控制：＞95%(还原性SDS-PAGE)

SOST制剂：冻干品

SOST保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

SOST复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于SOST：
Sclerostin, also known as SOST, is a member of the Cerberus/DAN family of BMP antagonists. SOST is asecreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain. It shows sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. SOST is produced by the osteocyte and has anti-anabolic effects on bone formation. It is a negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.


重组人Txndc4(Erp44) 分子生物学试剂关键词：重组人Txndc4蛋白,JN1145,重组人Erp44,重组Txndc4

ARB13220 小鼠黄嘌呤酶免分析 Mouse xanthione ELISA KIT
PY02-065  抗生素检定培养基Ⅲ号  250克  
F030811 BIOTIN标记山羊抗小鼠IgA抗体 Goat Anti-Mouse IgA*BIOTIN
加替沙星 5′-AMP 112811-59-3
BTN100839 潮霉素B干粉 Hygromycin B Powder
ARB12676 大鼠颗粒酶A(Gzms-A)elisa检测操作说明书 Rat granzymes a,gzms-a ELISA KIT
低糖DMEM(含双抗)   500ml
F020228 兔抗绵羊IgG抗体 Rabbit Anti-Sheep IgG
麦芽三糖 4-Dimethylaminobenzaldehyde 1109-28-0
ARB10344 人毛细血管扩张性共济失调突变基因(ATM)ELISA代测服务 Human ataxia telangiectasia mutated,atm ELISA KIT
D-虫荧光素* 2-Nitrobenzaldehyde 103404-75-7
ARB14063 豌豆凝集素(PSA)Elisa方法检测 Pisum sativum agglutinin,psa ELISA KIT
PY02-430  TAT肉汤基础  250克  
C0701 绵羊血清(无菌过滤)
F020213 山羊抗人IgM抗体 Goat Anti-Human IgM
ARB12827 小鼠小肠结肠炎耶尔森菌抗体(YersInIA enterocolItIcA Ab)含量检测 
ARB11175 人单胺氧化酶B(MAOB)检测服务 Human monoamine oxidase,mao ELISA KIT
F010106 小鼠抗His-tag抗体 Monoclonal Mouse Anti-His Tag
重组人Txndc4(Erp44) 分子生物学试剂关键词：重组人Txndc4蛋白,JN1145,重组人Erp44,重组Txndc4


·重组小鼠IL-27
编号：JN1645
英文名称：Recombinant Mouse Interleukin-27 subunit alpha and Interleukin-27 subunit beta
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Tyr19-Pro228&Phe29-Ser234在C端含有His标签。

IL-27质量控制：＞95%(还原性SDS-PAGE)

IL-27制剂：冻干品

IL-27保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

IL-27复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于IL-27：
IL-27 is a heterodimeric cytokine which belongs to the IL-6/IL-12 family of long type I cytokines. It is expressed on monocytes, endothelial cells and dendritic cells. IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive CD4(+) T cells and plays a role in the early regulation of Th1 cells initiation which drives efficient adaptive immune response. IL-27 potentiates the early phase of TH1 response and suppresses TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. IL-27 has an antiproliferative activity on melanomas through WSX-1/STAT1 signaling. Thus, IL-27 protein may be an attractive candidate as an antitumor agent applicable to cancer immunotherapy. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. IL-27 has also an effect on cytokine production. It suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9.

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