重组小鼠TIM-3(T细胞免疫球蛋白黏蛋白分子3) 分子生物

特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、医疗及其他非科研用途。

北京百奥莱博专业生产销*(代"售")重组小鼠TIM-3(T细胞免疫球蛋白黏蛋白分子3) 分子生物学试剂，我公司供应的分子生物学试剂品类齐全，且具有优势价格，欢迎新老客户垂询订购。

名称：重组小鼠TIM-3(T细胞免疫球蛋白黏蛋白分子3) 分子生物学试剂
英文名：Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3
规格：10μg|50μg|500μg|1mg
编号：JN1502
产地：国产|进口
品牌：百奥莱博
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Arg20-Arg191在C端含有His标签。

TIM-3 质量控制：＞95%(还原性SDS-PAGE)

TIM-3 制剂：冻干品

TIM-3 保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

TIM-3 复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于TIM-3 ：
T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in the Th1-mediated immune response. TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, and dendritic cells, but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosis of apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interaction with phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with an agonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is also regarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as two important coinhibitory regulators of T cell responses, have been implicated with the T-cell dysfunction or exhaustion associated with chronic HBV infection including HBV-related HCC.

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重组小鼠TIM-3(T细胞免疫球蛋白黏蛋白分子3) 分子生物学试剂关键词：重组小鼠TIM-3,重组TIM-3,重组小鼠TIM-3蛋白,重组小鼠T细胞免疫球蛋白黏蛋白分子3,JN1502


·重组小鼠干扰素γ(IFN-γ)
编号：JN0426
英文名称：Recombinant Mouse Interferon gamma
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的His23-Cys155表达纯化得来。

IFN-gamma/IFN-γ质量控制：＞95%(还原性SDS-PAGE)

IFN-gamma/IFN-γ制剂：冻干品

IFN-gamma/IFN-γ保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

IFN-gamma/IFN-γ复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于IFN-gamma/IFN-γ：
Mouse Ifng is a secreted protein which belongs to the type I I (or gamma) interferon family. IFNG is produced by lymphocytes and activated by specific antigens or mitogens. In addition to having antiviral activity, IFNG also has important immunoregulatory functions. It is a potent activator of macrophages and has antiproliferative effects on transformed cells. It can potentiate the antiviral and antitumor effects of the type I interferons. Genetic variation in IFNG is associated with the risk of aplastic anemia (AA) which is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.



重组小鼠TIM-3(T细胞免疫球蛋白黏蛋白分子3) 分子生物学试剂关键词：重组小鼠TIM-3,重组TIM-3,重组小鼠TIM-3蛋白,重组小鼠T细胞免疫球蛋白黏蛋白分子3,JN1502

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