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- Alomone
- 以色列
- AK-380
- 2025年07月14日
- 见官方网站
- 见说明书
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
见官方网站
- 亚型：
见官方网站
- 形态：
液体或冻干粉
- 保存条件：
-20°C
- 克隆性：
多克隆
- 标记物：
见官方网站
- 适应物种：
见官方网站
- 保质期：
6个月
- 抗原来源：
见说明书
- 目录编号：
AK-380
- 级别：
高
- 库存：
大量
- 供应商：
上海信裕生物科技有限公司
- 宿主：
见说明书
- 应用范围：
见官方网站
- 浓度：
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- 靶点：
见官方网站
- 抗体英文名：
P2X Receptor Antibodies for Pain Research Explorer Kit
- 抗体名：
P2X Receptor Antibodies for Pain Research Explorer Kit
- 规格：
16 Vials
P2X Receptor Antibodies for Pain Research Explorer Kit
A Screening Package of P2X Receptor Antibodies for Pain Research Economically PricedCat #: AK-380
16 Vials
Alomone Labs is pleased to offer the P2X Receptor Antibodies for Pain Research Explorer Kit (#AK-380). This Explorer Kit includes P2X receptor antibodies for pain research with their respective peptide control antigen. An ideal tool for screening purposes.
- Compounds
- Scientific Background
P2X receptors comprise a family of seven members (P2X1-7) of extracellular ATP-gated cation channels. They are expressed in somatic and nervous tissues. These receptors have been implicated in a variety of neurological, inflammatory and cardiovascular diseases1.
P2X receptors consist of two transmembrane subunits with a large extracellular domain, which shows conserved cysteine residues in all members of the family. P2X3 is the focus of pain pathways research due to its selective expression in nociceptive neurons. Interestingly, expression of P2X3 is species specific. While the rat form seems to be sensory neuron specific, in mice and human there is a broader pattern of expression, with some evidence for expression in cardiac muscle and motor neurons.
Immunocytochemistry studies have indicated an upregulation of P2X3 receptors in both DRG and dorsal horn neurons following neuropathic injury. ATP and thus P2X receptors play a significant role in pain pathways. Intrathecal administration of a P2X agonist produces a dose-dependent thermal hyperalgesic response which is blocked by P2X antagonists. ATP agonists do not cause a similar response in P2X1 receptors, suggesting it is not involved in this effect. Animals injected with P2X agonists exhibit overt nociceptive behaviour such as hindpaw lifting and licking2.
P2X receptors have also been implicated as having a major role in visceral sensory function and have been put forward as potential therapeutic targets for visceral pain such as IBD and IBS. ATP released from epithelium lining cells upon distention of hollow organs acts on the P2X receptors which relay the information to the CNS and subsequently cause pain3.
References
- Hausmann, R. et al. (2015) Curr. Med. Chem. 22, 799.
- Ding, Y. et al. (2000) J. Auton. Nerv. Syst. 81, 289.
- Deiteren, A et al. (2015) PLoS ONE 10, e0123810.
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文献和实验PriCells: Introduction of Isolation and Culture of Human Alveolar Epithelial Cells
differences in this specific area of cellular research has been systematically studied yet. 1.2. AECs ATII cells constitute about 60% of AECs and about 15% of all lung parenchymal cells, although they cover less than 5% of the alveolar air spaces of adult
of various receptor classes. (A ) GPCR with seven membrane‐spanning regions; (B‐E ) LGICs: (B ) glutamate receptor, (C ) P2X receptor, (D ) nAChR, and (E ) VGIC K+ ‐rectified inward (Kirs) receptor; (F ) STAT receptor; (G ) PTK growth factor receptor; (H
therapeutics such as small molecules, proteins, or monoclonal antibodies. The main obstacle to achieving in vivo gene silencing by RNAi technologies is delivery. Here we show that chemically modified short interfering RNAs (siRNAs) can silence an endogenous
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