ITGA5 & ITGB1 Heterodimer抗体

ITGA5 & ITGB1 Heterodimer抗体产品信息免疫原 : Recombinant Human ITGA5 & ITGB1 Heterodimer protein (Catalog#CT014-H2508H)

Antibody Type : Mouse Monoclonal Antibody ( Mouse mAb Service Platform )
克隆号 : 01
抗体宿主 : Mouse IgG1
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ITGA5 & ITGB1 Heterodimer (rh ITGA5 & ITGB1 Heterodimer; Catalog#CT014-H2508H; P08648, P05556-1; Met 1-Tyr 995, Met 1-Asp 728). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
ITGA5 & ITGB1 Heterodimer抗体 Background
Integrin alpha-5, also known as CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, CD49e and ITGA5, is a single-pass type I membrane protein which belongs to theintegrin alpha chain family. ITGA5 contains 7FG-GAP repeats. Integrin alpha-5 / beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Integrin beta-1, also known as Fibronectin receptor subunit beta, VLA-4 subunit beta, CD29 and ITGB1, is a single-pass type I membrane protein which belongs to theintegrin beta chain family. It contains oneVWFA domain. Integrin beta-1 / ITGB1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. It binds LGALS3BP and ITGB1BP3, when associated with alpha-7, but not with alpha-5. Integrin beta-1 / ITGB1 interacts with FLNA, FLNB and RANBP9. Integrin beta-1 / ITGB1 binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses.

Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen.Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Integrin alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1.
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