- $793
- Alomone
- 以色列
- AK-306
- 2025年07月15日
- 见官方网站
- 见说明书
- 见官方网站
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- 详细信息
- 技术资料
- 免疫原：
见官方网站
- 亚型：
见官方网站
- 形态：
液体或冻干粉
- 保存条件：
-20°C
- 克隆性：
多克隆
- 标记物：
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- 适应物种：
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- 保质期：
6个月
- 抗原来源：
见说明书
- 目录编号：
AK-306
- 级别：
高
- 库存：
大量
- 供应商：
上海信裕生物科技有限公司
- 宿主：
见说明书
- 应用范围：
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- 浓度：
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- 靶点：
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- 抗体英文名：
Mechanosensitive K2P Channel Antibody Explorer Kit
- 抗体名：
Mechanosensitive K2P Channel Antibody Explorer Kit
- 规格：
10 Vials
Mechanosensitive K2P Channel Antibody Explorer Kit
A Screening Package of Mechanosensitive K2P Channel Antibodies Economically PricedCat #: AK-306
10 Vials
Alomone Labs is pleased to offer the Mechanosensitive K2P Channel Antibody Explorer Kit (#AK-306). This Explorer Kit includes Mechanosensitive K2P Channel antibodies with their respective peptide control antigen. An ideal tool for screening purposes.
- Compounds
- Scientific Background
| Product Name | Cat # | Size |
|---|---|---|
Anti-K2P10.1 (TREK-2) |
APC-055 | 1 x 50 µl |
Anti-K2P18.1 (TRESK) (extracellular) |
APC-122 | 1 x 50 µl |
Anti-K2P4.1 (TRAAK) |
APC-108 | 1 x 50 µl |
Anti-K2P2.1 (TREK-1) |
APC-047 | 1 x 50 µl |
Guinea pig Anti-K2P2.1 (TREK-1) |
AGP-049 | 1 x 50 µl |
Note A Guinea pig polyclonal antibody (#AGP-049) is included in this Explorer Kit. Please take into account when reacting with a secondary antibody.
Scientific Background
Mechanosensitive ion channels (MS channels) represent a diverse population of ion channels. Other membrane-associated proteins with different biophysical properties apart from ion channels, specialized cytoskeletal proteins, cell junction molecules and G-protein-coupled receptors and kinases, among many others are also considered mechanosensitive1. MS channels integrate a variety of mechanical stimuli such as shear stress, tension, torsion, and compression and translate them into short-term effects (i.e., changes in ion concentrations and voltage) and long-term effects via changes in gene expression2.
MS channels are detected throughout evolution, from bacteria to higher order organisms including mammals3.
Two primary models have been proposed for mechanogating: the lipid bilayer stretch model evidenced by microbial MS channels and the more sophisticated tether model of eukaryotes by which tethers pull open the transduction channel4.
Recent studies have demonstrated that defects in mechanosensing potentially lead to diverse diseases and disorder, such as hearing loss, cardiomyopathies, muscular dystrophies, chronic pain, and cancer5.
Mechanosensitive K2P Channel Antibody Explorer KitReferences
- Anishkin, A. et al. (2013) Proc. Natl. Acad. Sci. U.S.A. 110, 4886.
- Delmas, P. et al. (2011) Nat. Rev. Neurosci. 12, 139.
- Pivetti, C.D. et al. (2003) Microbiol. Mol. Biol. Rev. 67, 66.
- Arnadottir, J. et al. (2010) Annu. Rev. Biophys. 39, 111.
- Delmas, P. et al. (2013) Cell. 155, 278.
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