A Screening Package of Glycine Receptor Antibodies Economically Priced
Cat #: AK-230
8 Vials
Alomone Labs is pleased to offer the Glycine Receptor Antibody Explorer Kit (#AK-230). This Explorer Kit includes antibodies targeting Glycine receptors along with their respective peptide control antigen. An ideal tool for screening purposes.
Compounds
Scientific Background
Related Products
Product Name
Cat #
Size
Anti-Glycine Receptor α1
AGR-001
1 x 50 µl
Anti-Glycine Receptor α3
AGR-003
1 x 50 µl
Anti-Glycine Receptor α4 (extracellular)
AGR-015
1 x 50 µl
Anti-Glycine Receptor β
AGR-014
1 x 50 µl
Scientific Background The amino acid glycine mediates neuronal inhibition by activating glycine receptors (GlyRs), which are ligand-gated chloride channels of the nicotinic acetylcholine receptor superfamily. GlyRs are known to mediate postsynaptic inhibition in spinal cord, brain stem and some higher brain regions1. GlyR is a member of the pentameric Cys-loop ion channel receptor family. Functional Cys-loop receptors comprise homomeric or heteromeric pentameric oligomers with each of the five subunits arranged symmetrically in a ring around a central ion-conducting pore. Several developmentally and regionally regulated GlyR isoforms exist, which result from a differential expression of the GlyR α (α1- α4) and β subunit genes. Each GlyR subunit comprises a large extracellular amino-terminal domain that harbors the ligand-binding sites and the eponymous Cys-loop. This connects to a bundle of four α-helical transmembrane domains (labelled M1–M4) with a large intracellular domain between M3 and M4 and a short extracellular C-terminal tail2.
Glycine Receptor Antibody Explorer KitReferences
Meyer, G. et al. (1995) Neuron15, 563.
Lynch, J.W. et al. (2009) Neuropharmacology56, 303.