Anti-CDH1 Polyclonal Antibody

英文名称Rabbit CDH1 Polyclonal Antibody别名ATG8A;GABARAP-a;MM46应用WB稀释比例WB1:500-1:1000交叉反应Mouse蛋白分子量97kDaGene ID999保存Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.储存液PBS with 0.02% sodium azide, 50% glycerol, pH7.3.纯化方法Affinity purification亚型IgG免疫原A synthetic peptide of human CDH1性状Lyophilized or LiquidSwiss ProtP12830克隆类型Polyclonal Antibody来源Rabbit背景资料This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.