Anti-ACTL6A Polyclonal Antibod

英文名称Rabbit ACTL6A Polyclonal Antibody应用WB,IHC,IF,IP,CHIP稀释比例WB1:500-1:2000 IHC1:50-1:200 IF1:50-1:200 IP1:50-1:200Ch IP1:20-1:100交叉反应Human,Mouse,Rat蛋白分子量47kDaGene ID86保存Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.储存液PBS with 0.02% sodium azide, 50% glycerol, pH7.3.纯化方法Affinity purification亚型IgG免疫原Recombinant protein of human ACTL6A性状Lyophilized or LiquidSwiss ProtO96019克隆类型Polyclonal Antibody来源Rabbit背景资料This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.